Cargando…
Acupuncture modulates temporal neural responses in wide brain networks: evidence from fMRI study
BACKGROUND: Accumulating neuroimaging studies in humans have shown that acupuncture can modulate a widely distributed brain network, large portions of which are overlapped with the pain-related areas. Recently, a striking feature of acupuncture-induced analgesia is found to be associated with its lo...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989943/ https://www.ncbi.nlm.nih.gov/pubmed/21044291 http://dx.doi.org/10.1186/1744-8069-6-73 |
_version_ | 1782192411715305472 |
---|---|
author | Bai, Lijun Tian, Jie Zhong, Chongguang Xue, Ting you, Youbo Liu, Zhenyu Chen, Peng Gong, Qiyong Ai, Lin Qin, Wei Dai, Jianping Liu, Yijun |
author_facet | Bai, Lijun Tian, Jie Zhong, Chongguang Xue, Ting you, Youbo Liu, Zhenyu Chen, Peng Gong, Qiyong Ai, Lin Qin, Wei Dai, Jianping Liu, Yijun |
author_sort | Bai, Lijun |
collection | PubMed |
description | BACKGROUND: Accumulating neuroimaging studies in humans have shown that acupuncture can modulate a widely distributed brain network, large portions of which are overlapped with the pain-related areas. Recently, a striking feature of acupuncture-induced analgesia is found to be associated with its long-last effect, which has a delayed onset and gradually reaches a peak even after acupuncture needling being terminated. Identifying temporal neural responses in these areas that occur at particular time -- both acute and sustained effects during acupuncture processes -- may therefore shed lights on how such peripheral inputs are conducted and mediated through the CNS. In the present study, we adopted a non-repeated event-related (NRER) fMRI paradigm and control theory based approach namely change-point analysis in order to capture the detailed temporal profile of neural responses induced by acupuncture. RESULTS: Our findings demonstrated that neural activities at the different stages of acupuncture presented distinct temporal patterns, in which consistently positive neural responses were found during the period of acupuncture needling while much more complex and dynamic activities found during a post-acupuncture period. These brain responses had a significant time-dependent effect which showed different onset time and duration of neural activities. The amygdala and perigenual anterior cingulate cortex (pACC), exhibited increased activities during the needling phase while decreased gradually to reach a peak below the baseline. The periaqueductal gray (PAG) and hypothalamus presented saliently intermittent activations across the whole fMRI session. Apart from the time-dependent responses, relatively persistent activities were also identified in the anterior insula and prefrontal cortices. The overall findings indicate that acupuncture may engage differential temporal neural responses as a function of time in a wide range of brain networks. CONCLUSIONS: Our study has provided evidence supporting a view that acupuncture intervention involves complex modulations of temporal neural response, and its effect can gradually resolve as a function of time. The functional specificity of acupuncture at ST36 may involve multiple levels of differential activities of a wide range of brain networks, which are gradually enhanced even after acupuncture needle being terminated. |
format | Text |
id | pubmed-2989943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29899432010-12-13 Acupuncture modulates temporal neural responses in wide brain networks: evidence from fMRI study Bai, Lijun Tian, Jie Zhong, Chongguang Xue, Ting you, Youbo Liu, Zhenyu Chen, Peng Gong, Qiyong Ai, Lin Qin, Wei Dai, Jianping Liu, Yijun Mol Pain Research BACKGROUND: Accumulating neuroimaging studies in humans have shown that acupuncture can modulate a widely distributed brain network, large portions of which are overlapped with the pain-related areas. Recently, a striking feature of acupuncture-induced analgesia is found to be associated with its long-last effect, which has a delayed onset and gradually reaches a peak even after acupuncture needling being terminated. Identifying temporal neural responses in these areas that occur at particular time -- both acute and sustained effects during acupuncture processes -- may therefore shed lights on how such peripheral inputs are conducted and mediated through the CNS. In the present study, we adopted a non-repeated event-related (NRER) fMRI paradigm and control theory based approach namely change-point analysis in order to capture the detailed temporal profile of neural responses induced by acupuncture. RESULTS: Our findings demonstrated that neural activities at the different stages of acupuncture presented distinct temporal patterns, in which consistently positive neural responses were found during the period of acupuncture needling while much more complex and dynamic activities found during a post-acupuncture period. These brain responses had a significant time-dependent effect which showed different onset time and duration of neural activities. The amygdala and perigenual anterior cingulate cortex (pACC), exhibited increased activities during the needling phase while decreased gradually to reach a peak below the baseline. The periaqueductal gray (PAG) and hypothalamus presented saliently intermittent activations across the whole fMRI session. Apart from the time-dependent responses, relatively persistent activities were also identified in the anterior insula and prefrontal cortices. The overall findings indicate that acupuncture may engage differential temporal neural responses as a function of time in a wide range of brain networks. CONCLUSIONS: Our study has provided evidence supporting a view that acupuncture intervention involves complex modulations of temporal neural response, and its effect can gradually resolve as a function of time. The functional specificity of acupuncture at ST36 may involve multiple levels of differential activities of a wide range of brain networks, which are gradually enhanced even after acupuncture needle being terminated. BioMed Central 2010-11-02 /pmc/articles/PMC2989943/ /pubmed/21044291 http://dx.doi.org/10.1186/1744-8069-6-73 Text en Copyright ©2010 Bai et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Bai, Lijun Tian, Jie Zhong, Chongguang Xue, Ting you, Youbo Liu, Zhenyu Chen, Peng Gong, Qiyong Ai, Lin Qin, Wei Dai, Jianping Liu, Yijun Acupuncture modulates temporal neural responses in wide brain networks: evidence from fMRI study |
title | Acupuncture modulates temporal neural responses in wide brain networks: evidence from fMRI study |
title_full | Acupuncture modulates temporal neural responses in wide brain networks: evidence from fMRI study |
title_fullStr | Acupuncture modulates temporal neural responses in wide brain networks: evidence from fMRI study |
title_full_unstemmed | Acupuncture modulates temporal neural responses in wide brain networks: evidence from fMRI study |
title_short | Acupuncture modulates temporal neural responses in wide brain networks: evidence from fMRI study |
title_sort | acupuncture modulates temporal neural responses in wide brain networks: evidence from fmri study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989943/ https://www.ncbi.nlm.nih.gov/pubmed/21044291 http://dx.doi.org/10.1186/1744-8069-6-73 |
work_keys_str_mv | AT bailijun acupuncturemodulatestemporalneuralresponsesinwidebrainnetworksevidencefromfmristudy AT tianjie acupuncturemodulatestemporalneuralresponsesinwidebrainnetworksevidencefromfmristudy AT zhongchongguang acupuncturemodulatestemporalneuralresponsesinwidebrainnetworksevidencefromfmristudy AT xueting acupuncturemodulatestemporalneuralresponsesinwidebrainnetworksevidencefromfmristudy AT youyoubo acupuncturemodulatestemporalneuralresponsesinwidebrainnetworksevidencefromfmristudy AT liuzhenyu acupuncturemodulatestemporalneuralresponsesinwidebrainnetworksevidencefromfmristudy AT chenpeng acupuncturemodulatestemporalneuralresponsesinwidebrainnetworksevidencefromfmristudy AT gongqiyong acupuncturemodulatestemporalneuralresponsesinwidebrainnetworksevidencefromfmristudy AT ailin acupuncturemodulatestemporalneuralresponsesinwidebrainnetworksevidencefromfmristudy AT qinwei acupuncturemodulatestemporalneuralresponsesinwidebrainnetworksevidencefromfmristudy AT daijianping acupuncturemodulatestemporalneuralresponsesinwidebrainnetworksevidencefromfmristudy AT liuyijun acupuncturemodulatestemporalneuralresponsesinwidebrainnetworksevidencefromfmristudy |