TARDIVE DYSKINESIA: A POTENTIAL NEW NEUROCHEMICAL ANIMAL MODEL

Conventional neurochemical animal models of tardive dyskinesia are based upon the production of dopamine postsynaptic receptor supersensitivity by the chronic administration of neuroleptics. This study demonstrates that the same result is obtained by injecting Sprague-Dawley rats with a single (‘hig...

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Detalles Bibliográficos
Autores principales: Andrade, Chittaranjan, Pradhan, N.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 1990
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990179/
https://www.ncbi.nlm.nih.gov/pubmed/21927470
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author Andrade, Chittaranjan
Pradhan, N.
author_facet Andrade, Chittaranjan
Pradhan, N.
author_sort Andrade, Chittaranjan
collection PubMed
description Conventional neurochemical animal models of tardive dyskinesia are based upon the production of dopamine postsynaptic receptor supersensitivity by the chronic administration of neuroleptics. This study demonstrates that the same result is obtained by injecting Sprague-Dawley rats with a single (‘high’) dose of ipomorphine. It is hence suggested that apomorphine-induced time-dependant potentiation of dopaminepostsynaptic receptor response may be a more convenient neurochemical animal model of tardive dyskinesia; related theoretical and practical issues are discussed briefly, as also he methodological differences between the present study and an earlier report.
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spelling pubmed-29901792011-09-16 TARDIVE DYSKINESIA: A POTENTIAL NEW NEUROCHEMICAL ANIMAL MODEL Andrade, Chittaranjan Pradhan, N. Indian J Psychiatry Original Article Conventional neurochemical animal models of tardive dyskinesia are based upon the production of dopamine postsynaptic receptor supersensitivity by the chronic administration of neuroleptics. This study demonstrates that the same result is obtained by injecting Sprague-Dawley rats with a single (‘high’) dose of ipomorphine. It is hence suggested that apomorphine-induced time-dependant potentiation of dopaminepostsynaptic receptor response may be a more convenient neurochemical animal model of tardive dyskinesia; related theoretical and practical issues are discussed briefly, as also he methodological differences between the present study and an earlier report. Medknow Publications 1990 /pmc/articles/PMC2990179/ /pubmed/21927470 Text en Copyright: © Indian Journal of Psychiatry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Andrade, Chittaranjan
Pradhan, N.
TARDIVE DYSKINESIA: A POTENTIAL NEW NEUROCHEMICAL ANIMAL MODEL
title TARDIVE DYSKINESIA: A POTENTIAL NEW NEUROCHEMICAL ANIMAL MODEL
title_full TARDIVE DYSKINESIA: A POTENTIAL NEW NEUROCHEMICAL ANIMAL MODEL
title_fullStr TARDIVE DYSKINESIA: A POTENTIAL NEW NEUROCHEMICAL ANIMAL MODEL
title_full_unstemmed TARDIVE DYSKINESIA: A POTENTIAL NEW NEUROCHEMICAL ANIMAL MODEL
title_short TARDIVE DYSKINESIA: A POTENTIAL NEW NEUROCHEMICAL ANIMAL MODEL
title_sort tardive dyskinesia: a potential new neurochemical animal model
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990179/
https://www.ncbi.nlm.nih.gov/pubmed/21927470
work_keys_str_mv AT andradechittaranjan tardivedyskinesiaapotentialnewneurochemicalanimalmodel
AT pradhann tardivedyskinesiaapotentialnewneurochemicalanimalmodel

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