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Schizophrenia is associated with an increase in cortical microRNA biogenesis

MicroRNA expression profiling and quantitative reverse transcription-PCR analysis of the superior temporal gyrus and the dorsolateral prefrontal cortex revealed a significant schizophrenia-associated increase in global microRNA expression. This change was associated with an elevation of primary micr...

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Detalles Bibliográficos
Autores principales: Beveridge, N J, Gardiner, E, Carroll, A P, Tooney, P A, Cairns, M J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990188/
https://www.ncbi.nlm.nih.gov/pubmed/19721432
http://dx.doi.org/10.1038/mp.2009.84
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author Beveridge, N J
Gardiner, E
Carroll, A P
Tooney, P A
Cairns, M J
author_facet Beveridge, N J
Gardiner, E
Carroll, A P
Tooney, P A
Cairns, M J
author_sort Beveridge, N J
collection PubMed
description MicroRNA expression profiling and quantitative reverse transcription-PCR analysis of the superior temporal gyrus and the dorsolateral prefrontal cortex revealed a significant schizophrenia-associated increase in global microRNA expression. This change was associated with an elevation of primary microRNA processing and corresponded with an increase in the microprocessor component DGCR8. The biological implications for this extensive increase in gene silencing are profound, and were exemplified by members of the miR-15 family and other related microRNA, which were significantly upregulated in both brain regions. This functionally convergent influence is overrepresented in pathways involved in synaptic plasticity and includes many genes and pathways associated with schizophrenia, some of which were substantiated in vitro by reporter gene assay. Given the magnitude of microRNA changes and their wide sphere of influence, this phenomenon could represent an important dimension in the pathogenesis of schizophrenia.
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spelling pubmed-29901882010-12-02 Schizophrenia is associated with an increase in cortical microRNA biogenesis Beveridge, N J Gardiner, E Carroll, A P Tooney, P A Cairns, M J Mol Psychiatry Original Article MicroRNA expression profiling and quantitative reverse transcription-PCR analysis of the superior temporal gyrus and the dorsolateral prefrontal cortex revealed a significant schizophrenia-associated increase in global microRNA expression. This change was associated with an elevation of primary microRNA processing and corresponded with an increase in the microprocessor component DGCR8. The biological implications for this extensive increase in gene silencing are profound, and were exemplified by members of the miR-15 family and other related microRNA, which were significantly upregulated in both brain regions. This functionally convergent influence is overrepresented in pathways involved in synaptic plasticity and includes many genes and pathways associated with schizophrenia, some of which were substantiated in vitro by reporter gene assay. Given the magnitude of microRNA changes and their wide sphere of influence, this phenomenon could represent an important dimension in the pathogenesis of schizophrenia. Nature Publishing Group 2010-12 2009-09-01 /pmc/articles/PMC2990188/ /pubmed/19721432 http://dx.doi.org/10.1038/mp.2009.84 Text en Copyright © 2010 Nature Publishing Group http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Original Article
Beveridge, N J
Gardiner, E
Carroll, A P
Tooney, P A
Cairns, M J
Schizophrenia is associated with an increase in cortical microRNA biogenesis
title Schizophrenia is associated with an increase in cortical microRNA biogenesis
title_full Schizophrenia is associated with an increase in cortical microRNA biogenesis
title_fullStr Schizophrenia is associated with an increase in cortical microRNA biogenesis
title_full_unstemmed Schizophrenia is associated with an increase in cortical microRNA biogenesis
title_short Schizophrenia is associated with an increase in cortical microRNA biogenesis
title_sort schizophrenia is associated with an increase in cortical microrna biogenesis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990188/
https://www.ncbi.nlm.nih.gov/pubmed/19721432
http://dx.doi.org/10.1038/mp.2009.84
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