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Relevance of Structural Brain Connectivity to Learning and Recovery from Stroke

The physical structure of white matter fiber bundles constrains their function. Any behavior that relies on transmission of signals along a particular pathway will therefore be influenced by the structural condition of that pathway. Diffusion-weighted magnetic resonance imaging provides localized me...

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Detalles Bibliográficos
Autores principales: Johansen-Berg, Heidi, Scholz, Jan, Stagg, Charlotte J.
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990506/
https://www.ncbi.nlm.nih.gov/pubmed/21119774
http://dx.doi.org/10.3389/fnsys.2010.00146
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author Johansen-Berg, Heidi
Scholz, Jan
Stagg, Charlotte J.
author_facet Johansen-Berg, Heidi
Scholz, Jan
Stagg, Charlotte J.
author_sort Johansen-Berg, Heidi
collection PubMed
description The physical structure of white matter fiber bundles constrains their function. Any behavior that relies on transmission of signals along a particular pathway will therefore be influenced by the structural condition of that pathway. Diffusion-weighted magnetic resonance imaging provides localized measures that are sensitive to white matter microstructure. In this review, we discuss imaging evidence on the relevance of white matter microstructure to behavior. We focus in particular on motor behavior and learning in healthy individuals and in individuals who have suffered a stroke. We provide examples of ways in which imaging measures of structural brain connectivity can inform our study of motor behavior and effects of motor training in three different domains: (1) to assess network degeneration or damage with healthy aging and following stroke, (2) to identify a structural basis for individual differences in behavioral responses, and (3) to test for dynamic changes in structural connectivity with learning or recovery.
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spelling pubmed-29905062010-11-30 Relevance of Structural Brain Connectivity to Learning and Recovery from Stroke Johansen-Berg, Heidi Scholz, Jan Stagg, Charlotte J. Front Syst Neurosci Neuroscience The physical structure of white matter fiber bundles constrains their function. Any behavior that relies on transmission of signals along a particular pathway will therefore be influenced by the structural condition of that pathway. Diffusion-weighted magnetic resonance imaging provides localized measures that are sensitive to white matter microstructure. In this review, we discuss imaging evidence on the relevance of white matter microstructure to behavior. We focus in particular on motor behavior and learning in healthy individuals and in individuals who have suffered a stroke. We provide examples of ways in which imaging measures of structural brain connectivity can inform our study of motor behavior and effects of motor training in three different domains: (1) to assess network degeneration or damage with healthy aging and following stroke, (2) to identify a structural basis for individual differences in behavioral responses, and (3) to test for dynamic changes in structural connectivity with learning or recovery. Frontiers Research Foundation 2010-11-02 /pmc/articles/PMC2990506/ /pubmed/21119774 http://dx.doi.org/10.3389/fnsys.2010.00146 Text en Copyright © 2010 Johansen-Berg, Scholz and Stagg. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Neuroscience
Johansen-Berg, Heidi
Scholz, Jan
Stagg, Charlotte J.
Relevance of Structural Brain Connectivity to Learning and Recovery from Stroke
title Relevance of Structural Brain Connectivity to Learning and Recovery from Stroke
title_full Relevance of Structural Brain Connectivity to Learning and Recovery from Stroke
title_fullStr Relevance of Structural Brain Connectivity to Learning and Recovery from Stroke
title_full_unstemmed Relevance of Structural Brain Connectivity to Learning and Recovery from Stroke
title_short Relevance of Structural Brain Connectivity to Learning and Recovery from Stroke
title_sort relevance of structural brain connectivity to learning and recovery from stroke
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990506/
https://www.ncbi.nlm.nih.gov/pubmed/21119774
http://dx.doi.org/10.3389/fnsys.2010.00146
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