Efficacy and Safety/Toxicity Study of Recombinant Vaccinia Virus JX-594 in Two Immunocompetent Animal Models of Glioma

The purpose of this study was to investigate the oncolytic potential of the recombinant, granulocyte macrophage colony-stimulating factor (GM-CSF)-expressing vaccinia virus (VV) JX-594 in experimental malignant glioma (MGs) in vitro and in immunocompetent rodent models. We have found that JX-594 kil...

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Detalles Bibliográficos
Autores principales: Lun, XueQing, Chan, Jennifer, Zhou, Hongyuan, Sun, Beichen, Kelly, John JP, Stechishin, Owen Owen, Bell, John C, Parato, Kelley, Hu, Kang, Vaillant, Dominique, Wang, Jiahu, Liu, Ta-Chiang, Breitbach, Caroline, Kirn, David, Senger, Donna L, Forsyth, Peter A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990519/
https://www.ncbi.nlm.nih.gov/pubmed/20808290
http://dx.doi.org/10.1038/mt.2010.183

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