Adiposity, adult weight change and breast cancer risk in postmenopausal Japanese women: the Miyagi Cohort Study

BACKGROUND: The role of adult weight change in breast cancer (BC) risk is unclear in Japanese women. METHODS: A total of 10 106 postmenopausal women aged 40–64 years (the Miyagi Cohort) were followed from 1990 to 2003, and 108 BC cases were identified. Hazard ratios (HRs) were estimated according to...

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Autores principales: Kawai, M, Minami, Y, Kuriyama, S, Kakizaki, M, Kakugawa, Y, Nishino, Y, Ishida, T, Fukao, A, Tsuji, I, Ohuchi, N
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990597/
https://www.ncbi.nlm.nih.gov/pubmed/20842123
http://dx.doi.org/10.1038/sj.bjc.6605885
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author Kawai, M
Minami, Y
Kuriyama, S
Kakizaki, M
Kakugawa, Y
Nishino, Y
Ishida, T
Fukao, A
Tsuji, I
Ohuchi, N
author_facet Kawai, M
Minami, Y
Kuriyama, S
Kakizaki, M
Kakugawa, Y
Nishino, Y
Ishida, T
Fukao, A
Tsuji, I
Ohuchi, N
author_sort Kawai, M
collection PubMed
description BACKGROUND: The role of adult weight change in breast cancer (BC) risk is unclear in Japanese women. METHODS: A total of 10 106 postmenopausal women aged 40–64 years (the Miyagi Cohort) were followed from 1990 to 2003, and 108 BC cases were identified. Hazard ratios (HRs) were estimated according to body mass index (BMI) at the current age and at the of age 20 years, and weight change since age 20 years. RESULTS: Higher current BMI was associated with an increased risk of BC (P for trend=0.02), whereas higher BMI at the age 20 years was inversely associated with this risk (P for trend=0.002). There was a significant association between weight change since age 20 years and BC risk (P for trend=0.0086). Compared with stable weight, HR was 0.35 for weight loss of 5 kg or more (P for weight loss trend=0.04) and 1.55 for weight gain of 12 kg or more (P for weight gain trend=0.05). CONCLUSION: Adiposity at younger and current age has differential effects on BC risk among postmenopausal women; weight gain in adulthood being associated with an increased, and weight loss with a decreased risk.
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spelling pubmed-29905972011-10-26 Adiposity, adult weight change and breast cancer risk in postmenopausal Japanese women: the Miyagi Cohort Study Kawai, M Minami, Y Kuriyama, S Kakizaki, M Kakugawa, Y Nishino, Y Ishida, T Fukao, A Tsuji, I Ohuchi, N Br J Cancer Epidemiology BACKGROUND: The role of adult weight change in breast cancer (BC) risk is unclear in Japanese women. METHODS: A total of 10 106 postmenopausal women aged 40–64 years (the Miyagi Cohort) were followed from 1990 to 2003, and 108 BC cases were identified. Hazard ratios (HRs) were estimated according to body mass index (BMI) at the current age and at the of age 20 years, and weight change since age 20 years. RESULTS: Higher current BMI was associated with an increased risk of BC (P for trend=0.02), whereas higher BMI at the age 20 years was inversely associated with this risk (P for trend=0.002). There was a significant association between weight change since age 20 years and BC risk (P for trend=0.0086). Compared with stable weight, HR was 0.35 for weight loss of 5 kg or more (P for weight loss trend=0.04) and 1.55 for weight gain of 12 kg or more (P for weight gain trend=0.05). CONCLUSION: Adiposity at younger and current age has differential effects on BC risk among postmenopausal women; weight gain in adulthood being associated with an increased, and weight loss with a decreased risk. Nature Publishing Group 2010-10-26 2010-09-14 /pmc/articles/PMC2990597/ /pubmed/20842123 http://dx.doi.org/10.1038/sj.bjc.6605885 Text en Copyright © 2010 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Kawai, M
Minami, Y
Kuriyama, S
Kakizaki, M
Kakugawa, Y
Nishino, Y
Ishida, T
Fukao, A
Tsuji, I
Ohuchi, N
Adiposity, adult weight change and breast cancer risk in postmenopausal Japanese women: the Miyagi Cohort Study
title Adiposity, adult weight change and breast cancer risk in postmenopausal Japanese women: the Miyagi Cohort Study
title_full Adiposity, adult weight change and breast cancer risk in postmenopausal Japanese women: the Miyagi Cohort Study
title_fullStr Adiposity, adult weight change and breast cancer risk in postmenopausal Japanese women: the Miyagi Cohort Study
title_full_unstemmed Adiposity, adult weight change and breast cancer risk in postmenopausal Japanese women: the Miyagi Cohort Study
title_short Adiposity, adult weight change and breast cancer risk in postmenopausal Japanese women: the Miyagi Cohort Study
title_sort adiposity, adult weight change and breast cancer risk in postmenopausal japanese women: the miyagi cohort study
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990597/
https://www.ncbi.nlm.nih.gov/pubmed/20842123
http://dx.doi.org/10.1038/sj.bjc.6605885
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