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A systematic review and meta-analysis of the relationship between body size and testicular cancer

BACKGROUND: Studies assessing the relationships of anthropometry and testicular germ-cell tumour (TGCT) have reported heterogeneous findings. METHODS: We undertook a systematic review and meta-analysis of the associations between adult height, weight, body mass index (BMI), and testicular cancer. Se...

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Autores principales: Lerro, C C, McGlynn, K A, Cook, M B
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990613/
https://www.ncbi.nlm.nih.gov/pubmed/20978513
http://dx.doi.org/10.1038/sj.bjc.6605934
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author Lerro, C C
McGlynn, K A
Cook, M B
author_facet Lerro, C C
McGlynn, K A
Cook, M B
author_sort Lerro, C C
collection PubMed
description BACKGROUND: Studies assessing the relationships of anthropometry and testicular germ-cell tumour (TGCT) have reported heterogeneous findings. METHODS: We undertook a systematic review and meta-analysis of the associations between adult height, weight, body mass index (BMI), and testicular cancer. Search strategies were conducted in PubMed, EMBASE, Scopus, and Web of Science on 26 May 2009. Studies that met our inclusion criteria were included in meta-analytic models using STATA 11. RESULTS: A total of 3255 references were retrieved, of which 14 met the inclusion criteria. Random effects meta-analysis found adult height (odds ratio (OR) per 5-cm increase 1.13, 95% confidence interval (CI) 1.07–1.19, P<0.001) and weight (OR overweight vs normal 0.92, 95% CI 0.86–0.98, P=0.011) to be associated with TGCT. The meta-analysis of weight and TGCT produced a summary estimate, which indicated no association, although an analysis restricted studies to North American was suggestive of association (OR per 1-kg increase 1.01, 95% CI 1.00–1.01, P<0.001). CONCLUSIONS: This systematic review and meta-analysis has found evidence for a positive association of adult height and TGCT, and tentative evidence for an inverse association of BMI and TGCT.
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spelling pubmed-29906132011-10-26 A systematic review and meta-analysis of the relationship between body size and testicular cancer Lerro, C C McGlynn, K A Cook, M B Br J Cancer Epidemiology BACKGROUND: Studies assessing the relationships of anthropometry and testicular germ-cell tumour (TGCT) have reported heterogeneous findings. METHODS: We undertook a systematic review and meta-analysis of the associations between adult height, weight, body mass index (BMI), and testicular cancer. Search strategies were conducted in PubMed, EMBASE, Scopus, and Web of Science on 26 May 2009. Studies that met our inclusion criteria were included in meta-analytic models using STATA 11. RESULTS: A total of 3255 references were retrieved, of which 14 met the inclusion criteria. Random effects meta-analysis found adult height (odds ratio (OR) per 5-cm increase 1.13, 95% confidence interval (CI) 1.07–1.19, P<0.001) and weight (OR overweight vs normal 0.92, 95% CI 0.86–0.98, P=0.011) to be associated with TGCT. The meta-analysis of weight and TGCT produced a summary estimate, which indicated no association, although an analysis restricted studies to North American was suggestive of association (OR per 1-kg increase 1.01, 95% CI 1.00–1.01, P<0.001). CONCLUSIONS: This systematic review and meta-analysis has found evidence for a positive association of adult height and TGCT, and tentative evidence for an inverse association of BMI and TGCT. Nature Publishing Group 2010-10-26 2010-10-26 /pmc/articles/PMC2990613/ /pubmed/20978513 http://dx.doi.org/10.1038/sj.bjc.6605934 Text en Copyright © 2010 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Lerro, C C
McGlynn, K A
Cook, M B
A systematic review and meta-analysis of the relationship between body size and testicular cancer
title A systematic review and meta-analysis of the relationship between body size and testicular cancer
title_full A systematic review and meta-analysis of the relationship between body size and testicular cancer
title_fullStr A systematic review and meta-analysis of the relationship between body size and testicular cancer
title_full_unstemmed A systematic review and meta-analysis of the relationship between body size and testicular cancer
title_short A systematic review and meta-analysis of the relationship between body size and testicular cancer
title_sort systematic review and meta-analysis of the relationship between body size and testicular cancer
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990613/
https://www.ncbi.nlm.nih.gov/pubmed/20978513
http://dx.doi.org/10.1038/sj.bjc.6605934
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