Plk4/SAK/ZYG-1 in the regulation of centriole duplication

Centrioles organize both centrosomes and cilia. Centriole duplication is tightly regulated and coordinated with the cell cycle to limit duplication to only once per cell cycle. Defects in centriole number and structure are commonly found in cancer. Plk4/SAK and the functionally related Caenorhabditi...

Descripción completa

Detalles Bibliográficos
Autores principales: Pearson, Chad G, Winey, Mark
Formato: Texto
Lenguaje:English
Publicado: Faculty of 1000 Ltd 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990628/
https://www.ncbi.nlm.nih.gov/pubmed/21173875
http://dx.doi.org/10.3410/B2-58
_version_ 1782192492124307456
author Pearson, Chad G
Winey, Mark
author_facet Pearson, Chad G
Winey, Mark
author_sort Pearson, Chad G
collection PubMed
description Centrioles organize both centrosomes and cilia. Centriole duplication is tightly regulated and coordinated with the cell cycle to limit duplication to only once per cell cycle. Defects in centriole number and structure are commonly found in cancer. Plk4/SAK and the functionally related Caenorhabditis elegans ZYG-1 kinases initiate centriole duplication. Several recent studies have elucidated the regulated activity of these kinases and potential downstream targets for centriole assembly.
format Text
id pubmed-2990628
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Faculty of 1000 Ltd
record_format MEDLINE/PubMed
spelling pubmed-29906282010-12-20 Plk4/SAK/ZYG-1 in the regulation of centriole duplication Pearson, Chad G Winey, Mark F1000 Biol Rep Review Article Centrioles organize both centrosomes and cilia. Centriole duplication is tightly regulated and coordinated with the cell cycle to limit duplication to only once per cell cycle. Defects in centriole number and structure are commonly found in cancer. Plk4/SAK and the functionally related Caenorhabditis elegans ZYG-1 kinases initiate centriole duplication. Several recent studies have elucidated the regulated activity of these kinases and potential downstream targets for centriole assembly. Faculty of 1000 Ltd 2010-08-09 /pmc/articles/PMC2990628/ /pubmed/21173875 http://dx.doi.org/10.3410/B2-58 Text en © 2010 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Pearson, Chad G
Winey, Mark
Plk4/SAK/ZYG-1 in the regulation of centriole duplication
title Plk4/SAK/ZYG-1 in the regulation of centriole duplication
title_full Plk4/SAK/ZYG-1 in the regulation of centriole duplication
title_fullStr Plk4/SAK/ZYG-1 in the regulation of centriole duplication
title_full_unstemmed Plk4/SAK/ZYG-1 in the regulation of centriole duplication
title_short Plk4/SAK/ZYG-1 in the regulation of centriole duplication
title_sort plk4/sak/zyg-1 in the regulation of centriole duplication
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990628/
https://www.ncbi.nlm.nih.gov/pubmed/21173875
http://dx.doi.org/10.3410/B2-58
work_keys_str_mv AT pearsonchadg plk4sakzyg1intheregulationofcentrioleduplication
AT wineymark plk4sakzyg1intheregulationofcentrioleduplication

Ejemplares similares