Influence of the Stability of a Fused Protein and Its Distance to the Amyloidogenic Segment on Fibril Formation

Conversion of native proteins into amyloid fibrils is irreversible and therefore it is difficult to study the interdependence of conformational stability and fibrillation by thermodynamic analyses. Here we approached this problem by fusing amyloidogenic poly-alanine segments derived from the N-termi...

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Detalles Bibliográficos
Autores principales: Buttstedt, Anja, Winter, Reno, Sackewitz, Mirko, Hause, Gerd, Schmid, Franz-Xaver, Schwarz, Elisabeth
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990761/
https://www.ncbi.nlm.nih.gov/pubmed/21124848
http://dx.doi.org/10.1371/journal.pone.0015436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990761/
https://www.ncbi.nlm.nih.gov/pubmed/21124848
http://dx.doi.org/10.1371/journal.pone.0015436

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