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Influence of the Stability of a Fused Protein and Its Distance to the Amyloidogenic Segment on Fibril Formation
Conversion of native proteins into amyloid fibrils is irreversible and therefore it is difficult to study the interdependence of conformational stability and fibrillation by thermodynamic analyses. Here we approached this problem by fusing amyloidogenic poly-alanine segments derived from the N-termi...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990761/ https://www.ncbi.nlm.nih.gov/pubmed/21124848 http://dx.doi.org/10.1371/journal.pone.0015436 |