Metabolically Stabilized Long-Circulating PEGylated Polyacridine Peptide Polyplexes Mediate Hydrodynamically Stimulated Gene Expression in Liver

A novel class of PEGylated polyacridine peptides was developed that mediate potent stimulated gene transfer in the liver of mice. Polyacridine peptides, (Acr-X)(n)-Cys-PEG, possessing 2–6 repeats of Lys-acridine (Acr) spaced by either Lys, Arg, Leu or Glu, were Cys derivatized with polyethylene glyc...

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Detalles Bibliográficos
Autores principales: Fernandez, Christian A., Baumhover, Nicholas J., Duskey, Jason T., Khargharia, Sanjib, Kizzire, Koby, Ericson, Mark D., Rice, Kevin G.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990782/
https://www.ncbi.nlm.nih.gov/pubmed/20720577
http://dx.doi.org/10.1038/gt.2010.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990782/
https://www.ncbi.nlm.nih.gov/pubmed/20720577
http://dx.doi.org/10.1038/gt.2010.117

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