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Sizing up stability: combination therapy with Apo-AI peptide mimetics and statins in systemic lupus erythematosus-mediated atherosclerosis
In a study published recently in Arthritis Research & Therapy, Woo and colleagues investigated the effects of pravastatin in combination with an apolipoprotein-AI (Apo-AI) mimetic peptide in a mouse model of lupus-accelerated atherosclerosis. Combination treatment resulted in a significant decre...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990990/ https://www.ncbi.nlm.nih.gov/pubmed/20854650 http://dx.doi.org/10.1186/ar3115 |
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author | Mendez-Fernandez, Yanice Major, Amy |
author_facet | Mendez-Fernandez, Yanice Major, Amy |
author_sort | Mendez-Fernandez, Yanice |
collection | PubMed |
description | In a study published recently in Arthritis Research & Therapy, Woo and colleagues investigated the effects of pravastatin in combination with an apolipoprotein-AI (Apo-AI) mimetic peptide in a mouse model of lupus-accelerated atherosclerosis. Combination treatment resulted in a significant decrease in systemic inflammation but increased aortic root lesion size. However, this treatment changed the phenotype of the lesion to a more stable plaque. Because plaque stability is also important for protection against the deadly manifestations of atherosclerosis, combination therapies using Apo-AI mimetics and statin might offer a good additional therapy to treat autoimmunity and cardiovascular disease in patients with lupus. |
format | Text |
id | pubmed-2990990 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29909902011-03-15 Sizing up stability: combination therapy with Apo-AI peptide mimetics and statins in systemic lupus erythematosus-mediated atherosclerosis Mendez-Fernandez, Yanice Major, Amy Arthritis Res Ther Editorial In a study published recently in Arthritis Research & Therapy, Woo and colleagues investigated the effects of pravastatin in combination with an apolipoprotein-AI (Apo-AI) mimetic peptide in a mouse model of lupus-accelerated atherosclerosis. Combination treatment resulted in a significant decrease in systemic inflammation but increased aortic root lesion size. However, this treatment changed the phenotype of the lesion to a more stable plaque. Because plaque stability is also important for protection against the deadly manifestations of atherosclerosis, combination therapies using Apo-AI mimetics and statin might offer a good additional therapy to treat autoimmunity and cardiovascular disease in patients with lupus. BioMed Central 2010 2010-09-15 /pmc/articles/PMC2990990/ /pubmed/20854650 http://dx.doi.org/10.1186/ar3115 Text en Copyright ©2010 BioMed Central Ltd |
spellingShingle | Editorial Mendez-Fernandez, Yanice Major, Amy Sizing up stability: combination therapy with Apo-AI peptide mimetics and statins in systemic lupus erythematosus-mediated atherosclerosis |
title | Sizing up stability: combination therapy with Apo-AI peptide mimetics and statins in systemic lupus erythematosus-mediated atherosclerosis |
title_full | Sizing up stability: combination therapy with Apo-AI peptide mimetics and statins in systemic lupus erythematosus-mediated atherosclerosis |
title_fullStr | Sizing up stability: combination therapy with Apo-AI peptide mimetics and statins in systemic lupus erythematosus-mediated atherosclerosis |
title_full_unstemmed | Sizing up stability: combination therapy with Apo-AI peptide mimetics and statins in systemic lupus erythematosus-mediated atherosclerosis |
title_short | Sizing up stability: combination therapy with Apo-AI peptide mimetics and statins in systemic lupus erythematosus-mediated atherosclerosis |
title_sort | sizing up stability: combination therapy with apo-ai peptide mimetics and statins in systemic lupus erythematosus-mediated atherosclerosis |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990990/ https://www.ncbi.nlm.nih.gov/pubmed/20854650 http://dx.doi.org/10.1186/ar3115 |
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