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Type I IFN and TNFα cross-regulation in immune-mediated inflammatory disease: basic concepts and clinical relevance

A cross-regulation between type I IFN and TNFα has been proposed recently, where both cytokines are hypothesized to counteract each other. According to this model, different autoimmune diseases can be viewed as disequilibrium between both cytokines. As this model may have important clinical implicat...

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Detalles Bibliográficos
Autores principales: Cantaert, Tineke, Baeten, Dominique, Tak, Paul P, van Baarsen, Lisa GM
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991015/
https://www.ncbi.nlm.nih.gov/pubmed/21062511
http://dx.doi.org/10.1186/ar3150
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author Cantaert, Tineke
Baeten, Dominique
Tak, Paul P
van Baarsen, Lisa GM
author_facet Cantaert, Tineke
Baeten, Dominique
Tak, Paul P
van Baarsen, Lisa GM
author_sort Cantaert, Tineke
collection PubMed
description A cross-regulation between type I IFN and TNFα has been proposed recently, where both cytokines are hypothesized to counteract each other. According to this model, different autoimmune diseases can be viewed as disequilibrium between both cytokines. As this model may have important clinical implications, the present review summarizes and discusses the currently available clinical evidence arguing for or against the proposed cross-regulation between TNFα and type I IFN. In addition, we review how this cross-regulation works at the cellular and molecular levels. Finally, we discuss the clinical relevance of this proposed cross-regulation for biological therapies such as type I IFN or anti-TNFα treatment.
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spelling pubmed-29910152011-04-28 Type I IFN and TNFα cross-regulation in immune-mediated inflammatory disease: basic concepts and clinical relevance Cantaert, Tineke Baeten, Dominique Tak, Paul P van Baarsen, Lisa GM Arthritis Res Ther Review A cross-regulation between type I IFN and TNFα has been proposed recently, where both cytokines are hypothesized to counteract each other. According to this model, different autoimmune diseases can be viewed as disequilibrium between both cytokines. As this model may have important clinical implications, the present review summarizes and discusses the currently available clinical evidence arguing for or against the proposed cross-regulation between TNFα and type I IFN. In addition, we review how this cross-regulation works at the cellular and molecular levels. Finally, we discuss the clinical relevance of this proposed cross-regulation for biological therapies such as type I IFN or anti-TNFα treatment. BioMed Central 2010 2010-10-28 /pmc/articles/PMC2991015/ /pubmed/21062511 http://dx.doi.org/10.1186/ar3150 Text en Copyright ©2010 BioMed Central Ltd
spellingShingle Review
Cantaert, Tineke
Baeten, Dominique
Tak, Paul P
van Baarsen, Lisa GM
Type I IFN and TNFα cross-regulation in immune-mediated inflammatory disease: basic concepts and clinical relevance
title Type I IFN and TNFα cross-regulation in immune-mediated inflammatory disease: basic concepts and clinical relevance
title_full Type I IFN and TNFα cross-regulation in immune-mediated inflammatory disease: basic concepts and clinical relevance
title_fullStr Type I IFN and TNFα cross-regulation in immune-mediated inflammatory disease: basic concepts and clinical relevance
title_full_unstemmed Type I IFN and TNFα cross-regulation in immune-mediated inflammatory disease: basic concepts and clinical relevance
title_short Type I IFN and TNFα cross-regulation in immune-mediated inflammatory disease: basic concepts and clinical relevance
title_sort type i ifn and tnfα cross-regulation in immune-mediated inflammatory disease: basic concepts and clinical relevance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991015/
https://www.ncbi.nlm.nih.gov/pubmed/21062511
http://dx.doi.org/10.1186/ar3150
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