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A phase 2 randomized, double-blind study of AMG 108, a fully human monoclonal antibody to IL-1R, in patients with rheumatoid arthritis

INTRODUCTION: Preclinical work has suggested that IL-1 plays a critical role in the pathogenesis of rheumatoid arthritis (RA). The objective of the present study was to determine the effect of a long-acting IL-1 receptor inhibitor, AMG 108, in a double-blind, placebo-controlled, parallel-dosing stud...

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Detalles Bibliográficos
Autores principales:	Cardiel, Mario H, Tak, Paul P, Bensen, William, Burch, Francis X, Forejtova, Sarka, Badurski, Janusz E, Kakkar, Tarundeep, Bevirt, Terry, Ni, Liyun, McCroskery, Ellen, Jahreis, Angelika, Zack, Debra J
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991028/ https://www.ncbi.nlm.nih.gov/pubmed/20950476 http://dx.doi.org/10.1186/ar3163

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