Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment

Epidemiological, preclinical and clinical studies demonstrated that chronic inflammation induced by hepatitis C virus (HCV) is crucial in hepatocellular carcinogenesis. The interaction between hepatocytes and microenvironment regards virus, inflammatory and immunocompetent cells, chemo- and cyto-kin...

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Detalles Bibliográficos
Autores principales: Castello, Giuseppe, Costantini, Susan, Scala, Stefania
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991329/
https://www.ncbi.nlm.nih.gov/pubmed/21047421
http://dx.doi.org/10.1186/1479-5876-8-109
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author Castello, Giuseppe
Costantini, Susan
Scala, Stefania
author_facet Castello, Giuseppe
Costantini, Susan
Scala, Stefania
author_sort Castello, Giuseppe
collection PubMed
description Epidemiological, preclinical and clinical studies demonstrated that chronic inflammation induced by hepatitis C virus (HCV) is crucial in hepatocellular carcinogenesis. The interaction between hepatocytes and microenvironment regards virus, inflammatory and immunocompetent cells, chemo- and cyto-kines, reactive oxygen species (ROS) and nitric oxide (NO), generating cell transformation. We suggest hepatocarcinoma (HCC) as a model in which the targeting of microenvironment determine neoplastic transformation. The present review focuses on: the role of inflammation in carcinogenesis, the clinical impact of HCC and the inadequacy of the actual therapy, the chemoprevention targeting the microenvironment.
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spelling pubmed-29913292010-11-25 Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment Castello, Giuseppe Costantini, Susan Scala, Stefania J Transl Med Review Epidemiological, preclinical and clinical studies demonstrated that chronic inflammation induced by hepatitis C virus (HCV) is crucial in hepatocellular carcinogenesis. The interaction between hepatocytes and microenvironment regards virus, inflammatory and immunocompetent cells, chemo- and cyto-kines, reactive oxygen species (ROS) and nitric oxide (NO), generating cell transformation. We suggest hepatocarcinoma (HCC) as a model in which the targeting of microenvironment determine neoplastic transformation. The present review focuses on: the role of inflammation in carcinogenesis, the clinical impact of HCC and the inadequacy of the actual therapy, the chemoprevention targeting the microenvironment. BioMed Central 2010-11-03 /pmc/articles/PMC2991329/ /pubmed/21047421 http://dx.doi.org/10.1186/1479-5876-8-109 Text en Copyright ©2010 Castello et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Castello, Giuseppe
Costantini, Susan
Scala, Stefania
Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment
title Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment
title_full Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment
title_fullStr Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment
title_full_unstemmed Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment
title_short Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment
title_sort targeting the inflammation in hcv-associated hepatocellular carcinoma: a role in the prevention and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991329/
https://www.ncbi.nlm.nih.gov/pubmed/21047421
http://dx.doi.org/10.1186/1479-5876-8-109
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AT scalastefania targetingtheinflammationinhcvassociatedhepatocellularcarcinomaaroleinthepreventionandtreatment

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