The CD45 77C/G allele is not associated with myasthenia gravis - a reassessment of the potential role of CD45 in autoimmunity

BACKGROUND: The G allele of the CD45 77C/G SNP (rs17612648), which has previously been suggested to be associated with autoimmune disorders, was genotyped in 446 Swedish myasthenia gravis (MG) patients and 2303 matched controls. RESULTS: There was no association between the polymorphism and patient...

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Autores principales: Ramanujam, Ryan, Pirskanen, Ritva, Hammarström, Lennart
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991343/
https://www.ncbi.nlm.nih.gov/pubmed/21067564
http://dx.doi.org/10.1186/1756-0500-3-292
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author Ramanujam, Ryan
Pirskanen, Ritva
Hammarström, Lennart
author_facet Ramanujam, Ryan
Pirskanen, Ritva
Hammarström, Lennart
author_sort Ramanujam, Ryan
collection PubMed
description BACKGROUND: The G allele of the CD45 77C/G SNP (rs17612648), which has previously been suggested to be associated with autoimmune disorders, was genotyped in 446 Swedish myasthenia gravis (MG) patients and 2303 matched controls. RESULTS: There was no association between the polymorphism and patient group as a whole (p = 0.199), nor with clinical subgroups. Our results add to a growing number of studies unable to find association between the 77C/G polymorphism and autoimmune disorders. One control sample, from an adult blood donor, was homozygous for the G allele, yet negative for a panel of auto-antibodies, representing the first homozygous individual studied in this respect. CONCLUSIONS: The 77C/G mutation does not predispose to MG, and its role in autoimmunity may have to be re-evaluated.
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spelling pubmed-29913432010-11-25 The CD45 77C/G allele is not associated with myasthenia gravis - a reassessment of the potential role of CD45 in autoimmunity Ramanujam, Ryan Pirskanen, Ritva Hammarström, Lennart BMC Res Notes Research Article BACKGROUND: The G allele of the CD45 77C/G SNP (rs17612648), which has previously been suggested to be associated with autoimmune disorders, was genotyped in 446 Swedish myasthenia gravis (MG) patients and 2303 matched controls. RESULTS: There was no association between the polymorphism and patient group as a whole (p = 0.199), nor with clinical subgroups. Our results add to a growing number of studies unable to find association between the 77C/G polymorphism and autoimmune disorders. One control sample, from an adult blood donor, was homozygous for the G allele, yet negative for a panel of auto-antibodies, representing the first homozygous individual studied in this respect. CONCLUSIONS: The 77C/G mutation does not predispose to MG, and its role in autoimmunity may have to be re-evaluated. BioMed Central 2010-11-10 /pmc/articles/PMC2991343/ /pubmed/21067564 http://dx.doi.org/10.1186/1756-0500-3-292 Text en Copyright ©2010 Hammarström et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ramanujam, Ryan
Pirskanen, Ritva
Hammarström, Lennart
The CD45 77C/G allele is not associated with myasthenia gravis - a reassessment of the potential role of CD45 in autoimmunity
title The CD45 77C/G allele is not associated with myasthenia gravis - a reassessment of the potential role of CD45 in autoimmunity
title_full The CD45 77C/G allele is not associated with myasthenia gravis - a reassessment of the potential role of CD45 in autoimmunity
title_fullStr The CD45 77C/G allele is not associated with myasthenia gravis - a reassessment of the potential role of CD45 in autoimmunity
title_full_unstemmed The CD45 77C/G allele is not associated with myasthenia gravis - a reassessment of the potential role of CD45 in autoimmunity
title_short The CD45 77C/G allele is not associated with myasthenia gravis - a reassessment of the potential role of CD45 in autoimmunity
title_sort cd45 77c/g allele is not associated with myasthenia gravis - a reassessment of the potential role of cd45 in autoimmunity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991343/
https://www.ncbi.nlm.nih.gov/pubmed/21067564
http://dx.doi.org/10.1186/1756-0500-3-292
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