A COMPARATIVE STUDY OF DOTHIEPIN (PROTHIADEN) AND IMIPRAMINE IN DEPRESSION

In a single-blind, randomised, parallel-group study comparing the efficacy and tolerability of dothiepin (50-150 mg per day) and imipramine (50-150 mg per day) for 6 weeks, involving 60 adult patients with depression, it was observed that dothiepin was comparable to imipramine in terms of efficacy a...

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Detalles Bibliográficos
Autores principales: Vyas, J.N., Sharma, Pradeep, Singhal, Ashok K., Agarwal, Savita
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 1989
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991677/
https://www.ncbi.nlm.nih.gov/pubmed/21927374
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author Vyas, J.N.
Sharma, Pradeep
Singhal, Ashok K.
Agarwal, Savita
author_facet Vyas, J.N.
Sharma, Pradeep
Singhal, Ashok K.
Agarwal, Savita
author_sort Vyas, J.N.
collection PubMed
description In a single-blind, randomised, parallel-group study comparing the efficacy and tolerability of dothiepin (50-150 mg per day) and imipramine (50-150 mg per day) for 6 weeks, involving 60 adult patients with depression, it was observed that dothiepin was comparable to imipramine in terms of efficacy as assessed by Hamilton Rating Scale for depress ion, global scale for severty of illness and clinician′s overall assessment of efficacy. Dothiepin was found to have a significantly earlier onset of anxiolytic action compared to imipramine. Dothiepin was well tolerated.
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spelling pubmed-29916772011-09-16 A COMPARATIVE STUDY OF DOTHIEPIN (PROTHIADEN) AND IMIPRAMINE IN DEPRESSION Vyas, J.N. Sharma, Pradeep Singhal, Ashok K. Agarwal, Savita Indian J Psychiatry Original Article In a single-blind, randomised, parallel-group study comparing the efficacy and tolerability of dothiepin (50-150 mg per day) and imipramine (50-150 mg per day) for 6 weeks, involving 60 adult patients with depression, it was observed that dothiepin was comparable to imipramine in terms of efficacy as assessed by Hamilton Rating Scale for depress ion, global scale for severty of illness and clinician′s overall assessment of efficacy. Dothiepin was found to have a significantly earlier onset of anxiolytic action compared to imipramine. Dothiepin was well tolerated. Medknow Publications 1989 /pmc/articles/PMC2991677/ /pubmed/21927374 Text en Copyright: © Indian Journal of Psychiatry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Vyas, J.N.
Sharma, Pradeep
Singhal, Ashok K.
Agarwal, Savita
A COMPARATIVE STUDY OF DOTHIEPIN (PROTHIADEN) AND IMIPRAMINE IN DEPRESSION
title A COMPARATIVE STUDY OF DOTHIEPIN (PROTHIADEN) AND IMIPRAMINE IN DEPRESSION
title_full A COMPARATIVE STUDY OF DOTHIEPIN (PROTHIADEN) AND IMIPRAMINE IN DEPRESSION
title_fullStr A COMPARATIVE STUDY OF DOTHIEPIN (PROTHIADEN) AND IMIPRAMINE IN DEPRESSION
title_full_unstemmed A COMPARATIVE STUDY OF DOTHIEPIN (PROTHIADEN) AND IMIPRAMINE IN DEPRESSION
title_short A COMPARATIVE STUDY OF DOTHIEPIN (PROTHIADEN) AND IMIPRAMINE IN DEPRESSION
title_sort comparative study of dothiepin (prothiaden) and imipramine in depression
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991677/
https://www.ncbi.nlm.nih.gov/pubmed/21927374
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