Therapeutic misadventure with paracetamol in children

Paracetamol (acetaminophen), though considered a safe, “over the counter” analgesic and antipyretic, can cause liver injury with overdose. Therapeutic misadventure is a unique problem where the existing nomogram used for acute poisoning is not applicable. In this context, early initiation of N-acety...

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Detalles Bibliográficos
Autores principales: Shivbalan, So, Sathiyasekeran, Malathi, Thomas, Kuruvilla
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991705/
https://www.ncbi.nlm.nih.gov/pubmed/21189918
http://dx.doi.org/10.4103/0253-7613.71894
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author Shivbalan, So
Sathiyasekeran, Malathi
Thomas, Kuruvilla
author_facet Shivbalan, So
Sathiyasekeran, Malathi
Thomas, Kuruvilla
author_sort Shivbalan, So
collection PubMed
description Paracetamol (acetaminophen), though considered a safe, “over the counter” analgesic and antipyretic, can cause liver injury with overdose. Therapeutic misadventure is a unique problem where the existing nomogram used for acute poisoning is not applicable. In this context, early initiation of N-acetylcysteine even before a biochemical evidence of liver injury may be beneficial. A series of 6 children with this type of paracetamol overdose are presented here to increase the awareness and understanding of this problem since no such data is available from India.
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spelling pubmed-29917052010-12-28 Therapeutic misadventure with paracetamol in children Shivbalan, So Sathiyasekeran, Malathi Thomas, Kuruvilla Indian J Pharmacol Short Communication Paracetamol (acetaminophen), though considered a safe, “over the counter” analgesic and antipyretic, can cause liver injury with overdose. Therapeutic misadventure is a unique problem where the existing nomogram used for acute poisoning is not applicable. In this context, early initiation of N-acetylcysteine even before a biochemical evidence of liver injury may be beneficial. A series of 6 children with this type of paracetamol overdose are presented here to increase the awareness and understanding of this problem since no such data is available from India. Medknow Publications 2010-12 /pmc/articles/PMC2991705/ /pubmed/21189918 http://dx.doi.org/10.4103/0253-7613.71894 Text en © Indian Journal of Pharmacology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Shivbalan, So
Sathiyasekeran, Malathi
Thomas, Kuruvilla
Therapeutic misadventure with paracetamol in children
title Therapeutic misadventure with paracetamol in children
title_full Therapeutic misadventure with paracetamol in children
title_fullStr Therapeutic misadventure with paracetamol in children
title_full_unstemmed Therapeutic misadventure with paracetamol in children
title_short Therapeutic misadventure with paracetamol in children
title_sort therapeutic misadventure with paracetamol in children
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991705/
https://www.ncbi.nlm.nih.gov/pubmed/21189918
http://dx.doi.org/10.4103/0253-7613.71894
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