Use of type I interferon-inducible mRNAs as pharmacodynamic markers and potential diagnostic markers in trials with sifalimumab, an anti-IFNα antibody, in systemic lupus erythematosus

Type I interferons are implicated in the pathogenesis of systemic lupus erythematosus (SLE). Type I interferon-inducible mRNAs are widely and concordantly overexpressed in the periphery and involved tissues of a subset of SLE patients, and provide utility as pharmacodynamic biomarkers to aid dose se...

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Detalles Bibliográficos
Autores principales: Yao, Yihong, Higgs, Brandon W, Richman, Laura, White, Barbara, Jallal, Bahija
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991779/
https://www.ncbi.nlm.nih.gov/pubmed/20392292
http://dx.doi.org/10.1186/ar2887

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