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An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca(2+) Signals

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a ubiquitous messenger proposed to stimulate Ca(2+) release from acidic organelles via two-pore channels (TPCs). It has been difficult to resolve this trigger event from its amplification via endoplasmic reticulum Ca(2+) stores, fuelling specu...

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Detalles Bibliográficos
Autores principales:	Brailoiu, Eugen, Rahman, Taufiq, Churamani, Dev, Prole, David L., Brailoiu, G. Cristina, Hooper, Robert, Taylor, Colin W., Patel, Sandip
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992283/ https://www.ncbi.nlm.nih.gov/pubmed/20880839 http://dx.doi.org/10.1074/jbc.M110.162073

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