Cargando…

An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca(2+) Signals

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a ubiquitous messenger proposed to stimulate Ca(2+) release from acidic organelles via two-pore channels (TPCs). It has been difficult to resolve this trigger event from its amplification via endoplasmic reticulum Ca(2+) stores, fuelling specu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brailoiu, Eugen, Rahman, Taufiq, Churamani, Dev, Prole, David L., Brailoiu, G. Cristina, Hooper, Robert, Taylor, Colin W., Patel, Sandip
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992283/ https://www.ncbi.nlm.nih.gov/pubmed/20880839 http://dx.doi.org/10.1074/jbc.M110.162073

Ejemplares similares

Membrane Topology of NAADP-sensitive Two-pore Channels and Their Regulation by N-linked Glycosylation
por: Hooper, Robert, et al.
Publicado: (2011)

Domain assembly of NAADP-gated two-pore channels
por: Churamani, Dev, et al.
Publicado: (2011)

NAADP-evoked Ca(2+) signals through two-pore channel-1 require arginine residues in the first S4-S5 linker
por: Patel, Sandip, et al.
Publicado: (2017)

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling
por: Brailoiu, Eugen, et al.
Publicado: (2009)

Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart
por: Capel, Rebecca A., et al.
Publicado: (2015)

How does NAADP release lysosomal Ca(2+)?
por: Jha, Archana, et al.
Publicado: (2014)

Photoaffinity Labeling of High Affinity Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Binding Proteins in Sea Urchin Egg
por: Walseth, Timothy F., et al.
Publicado: (2012)

TPC2 Proteins Mediate Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)- and Agonist-evoked Contractions of Smooth Muscle
por: Tugba Durlu-Kandilci, Nezahat, et al.
Publicado: (2010)

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Calcium Signaling and Arrhythmias in the Heart Evoked by β-Adrenergic Stimulation
por: Nebel, Merle, et al.
Publicado: (2013)

Uncoupling Protein 3 (UCP3) Modulates the Activity of Sarco/Endoplasmic Reticulum Ca(2+)-ATPase (SERCA) by Decreasing Mitochondrial ATP Production
por: De Marchi, Umberto, et al.
Publicado: (2011)

Understanding How Components of a Ca(2+) Release-activated Ca(2+) Channel Function♦: The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1
Publicado: (2013)

Upregulation of Mitochondrial Uncoupling Protein-2 by the AMP-Activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes
por: Xie, Zhonglin, et al.
Publicado: (2008)

Regulation of Inositol 1,4,5-Trisphosphate Receptors by cAMP Independent of cAMP-dependent Protein Kinase
por: Tovey, Stephen C., et al.
Publicado: (2010)

Cooperativeness of Orai Cytosolic Domains Tunes Subtype-specific Gating
por: Frischauf, Irene, et al.
Publicado: (2011)

Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH
por: Lu, Yingying, et al.
Publicado: (2013)

Ca(2+) Signals Generated by CatSper and Ca(2+) Stores Regulate Different Behaviors in Human Sperm
por: Alasmari, Wardah, et al.
Publicado: (2013)

Lobe-specific Functions of Ca(2+)·Calmodulin in αCa(2+)·Calmodulin-dependent Protein Kinase II Activation
por: Jama, Abdirahman M., et al.
Publicado: (2011)

Molecular Determinants within N Terminus of Orai3 Protein That Control Channel Activation and Gating
por: Bergsmann, Judith, et al.
Publicado: (2011)

Caveolin-1 Alters the Pattern of Cytoplasmic Ca(2+) Oscillations and Ca(2+)-dependent Gene Expression by Enhancing Leukotriene Receptor Desensitization
por: Yeh, Yi-Chun, et al.
Publicado: (2014)

Molecularly Distinct Routes of Mitochondrial Ca(2+) Uptake Are Activated Depending on the Activity of the Sarco/Endoplasmic Reticulum Ca(2+) ATPase (SERCA)
por: Waldeck-Weiermair, Markus, et al.
Publicado: (2013)

The Sigma-1 Receptor Binds to the Nav1.5 Voltage-gated Na(+) Channel with 4-Fold Symmetry
por: Balasuriya, Dilshan, et al.
Publicado: (2012)

Local Cytosolic Ca(2+) Elevations Are Required for Stromal Interaction Molecule 1 (STIM1) De-oligomerization and Termination of Store-operated Ca(2+) Entry
por: Shen, Wei-Wei, et al.
Publicado: (2011)

Do Caveolae Have a Role in the Fidelity and Dynamics of Receptor Activation of G-protein-gated Inwardly Rectifying Potassium Channels?
por: Schwarzer, Sarah, et al.
Publicado: (2010)

Signaling to Extracellular Signal-regulated Kinase from ErbB1 Kinase and Protein Kinase C: FEEDBACK, HETEROGENEITY, AND GATING
por: Perrett, Rebecca M, et al.
Publicado: (2013)

Heat Shock Protein 90 Inhibitors Reduce Trafficking of ATP-gated P2X1 Receptors and Human Platelet Responsiveness
por: Lalo, Ulyana, et al.
Publicado: (2012)

The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1
por: Derler, Isabella, et al.
Publicado: (2013)

Calcium Elevation in Mitochondria Is the Main Ca(2+) Requirement for Mitochondrial Permeability Transition Pore (mPTP) Opening
por: Baumgartner, Heidi K., et al.
Publicado: (2009)

Cysteine Scanning Mutagenesis (Residues Glu(52)–Gly(96)) of the Human P2X1 Receptor for ATP: MAPPING AGONIST BINDING AND CHANNEL GATING
por: Allsopp, Rebecca C., et al.
Publicado: (2011)

Glucose-Induced Nuclear Shuttling of ChREBP Is Mediated by Sorcin and Ca(2+) Ions in Pancreatic β-Cells
por: Noordeen, Nafeesa A., et al.
Publicado: (2012)

Submaximal Inhibition of Protein Kinase C Restores ADP-induced Dense Granule Secretion in Platelets in the Presence of Ca(2+)
por: Unsworth, Amanda J., et al.
Publicado: (2011)

Inhibition of Cardiomyocytes Differentiation of Mouse Embryonic Stem Cells by CD38/cADPR/Ca(2+) Signaling Pathway
por: Wei, Wen-Jie, et al.
Publicado: (2012)

AKAP79/150 Interacts with AC8 and Regulates Ca(2+)-dependent cAMP Synthesis in Pancreatic and Neuronal Systems
por: Willoughby, Debbie, et al.
Publicado: (2010)

Increase in Serum Ca(2+/)Mg(2+) Ratio Promotes Proliferation of Prostate Cancer Cells by Activating TRPM7 Channels
por: Sun, Yuyang, et al.
Publicado: (2013)

Cavβ3 Regulates Ca(2+) Signaling and Insulin Expression in Pancreatic β-Cells in a Cell-Autonomous Manner
por: Becker, Alexander, et al.
Publicado: (2021)

Protein Kinase Cθ Negatively Regulates Store-independent Ca(2+) Entry and Phosphatidylserine Exposure Downstream of Glycoprotein VI in Platelets
por: Harper, Matthew T., et al.
Publicado: (2010)

Ca(2+)-mediated Mitochondrial Reactive Oxygen Species Metabolism Augments Wnt/β-Catenin Pathway Activation to Facilitate Cell Differentiation
por: Rharass, Tareck, et al.
Publicado: (2014)

Canonical Transient Receptor Potential (TRPC) 1 Acts as a Negative Regulator for Vanilloid TRPV6-mediated Ca(2+) Influx
por: Schindl, Rainer, et al.
Publicado: (2012)

Monophosphorylation of cardiac troponin-I at Ser-23/24 is sufficient to regulate cardiac myofibrillar Ca(2+) sensitivity and calpain-induced proteolysis
por: Martin-Garrido, Abel, et al.
Publicado: (2018)

The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca(2+) dynamics in adult mice
por: Mitchell, Ryan K., et al.
Publicado: (2017)

Elevated Carbon Dioxide Blunts Mammalian cAMP Signaling Dependent on Inositol 1,4,5-Triphosphate Receptor-mediated Ca(2+) Release
por: Cook, Zara C., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_28prb6n68d4clqi9vkbc1sicbp