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A Structural Determinant for the Control of PIP(2) Sensitivity in G Protein-gated Inward Rectifier K(+) Channels

Inward rectifier K(+) (Kir) channels are activated by phosphatidylinositol-(4,5)-bisphosphate (PIP(2)), but G protein-gated Kir (K(G)) channels further require either G protein βγ subunits (Gβγ) or intracellular Na(+) for their activation. To reveal the mechanism(s) underlying this regulation, we co...

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Detalles Bibliográficos
Autores principales:	Inanobe, Atsushi, Nakagawa, Atsushi, Matsuura, Takanori, Kurachi, Yoshihisa
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Membrane Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992284/ https://www.ncbi.nlm.nih.gov/pubmed/20880843 http://dx.doi.org/10.1074/jbc.M110.161703

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