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Regulation of PURA gene transcription by three promoters generating distinctly spliced 5-prime leaders: a novel means of fine control over tissue specificity and viral signals

BACKGROUND: Purα is an evolutionarily conserved cellular protein participating in processes of DNA replication, transcription, and RNA transport; all involving binding to nucleic acids and altering conformation and physical positioning. The distinct but related roles of Purα suggest a need for expre...

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Detalles Bibliográficos
Autores principales: Wortman, Margaret J, Hanson, Laura K, Martínez-Sobrido, Luis, Campbell, Ann E, Nance, Jonas A, García-Sastre, Adolfo, Johnson, Edward M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992531/
https://www.ncbi.nlm.nih.gov/pubmed/21062477
http://dx.doi.org/10.1186/1471-2199-11-81