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In Vivo Expression of HGF/NK1 and GLP-1 From dsAAV Vectors Enhances Pancreatic β-Cell Proliferation and Improves Pathology in the db/db Mouse Model of Diabetes

OBJECTIVE: The purpose of the current study was to determine whether double-stranded adeno-associated virus (dsAAV)-mediated in vivo expression of β-cell growth factors, glucagon-like peptide-1 (GLP-1) and the NK1 fragment of hepatocyte growth factor (HGF/NK1) in β-cells, improves pathology in the d...

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Detalles Bibliográficos
Autores principales:	Gaddy, Daniel F., Riedel, Michael J., Pejawar-Gaddy, Sharmila, Kieffer, Timothy J., Robbins, Paul D.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992772/ https://www.ncbi.nlm.nih.gov/pubmed/20841608 http://dx.doi.org/10.2337/db09-1886

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