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High Glucose Increases Lysyl Oxidase Expression and Activity in Retinal Endothelial Cells: Mechanism for Compromised Extracellular Matrix Barrier Function

OBJECTIVE: In diabetes, retinal vascular basement membrane (BM) undergoes significant thickening and compromises vessel function including increased vascular permeability, a prominent lesion of early diabetic retinopathy. In this study we determined whether altered expression and activity of lysyl o...

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Detalles Bibliográficos
Autores principales:	Chronopoulos, Argyrios, Tang, Amanda, Beglova, Ekaterina, Trackman, Philip C., Roy, Sayon
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Pathophysiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992778/ https://www.ncbi.nlm.nih.gov/pubmed/20823103 http://dx.doi.org/10.2337/db10-0365

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