Cargando…

Candesartan Attenuates Diabetic Retinal Vascular Pathology by Restoring Glyoxalase-I Function

OBJECTIVE: Advanced glycation end products (AGEs) and the renin-angiotensin system (RAS) are both implicated in the development of diabetic retinopathy. How these pathways interact to promote retinal vasculopathy is not fully understood. Glyoxalase-I (GLO-I) is an enzyme critical for the detoxificat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Miller, Antonia G., Tan, Genevieve, Binger, Katrina J., Pickering, Raelene J., Thomas, Merlin C., Nagaraj, Ram H., Cooper, Mark E., Wilkinson-Berka, Jennifer L.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Complications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992784/ https://www.ncbi.nlm.nih.gov/pubmed/20852029 http://dx.doi.org/10.2337/db10-0552

Ejemplares similares

Knockdown of Glyoxalase 1 Mimics Diabetic Nephropathy in Nondiabetic Mice
por: Giacco, Ferdinando, et al.
Publicado: (2014)

Alagebrium Reduces Glomerular Fibrogenesis and Inflammation Beyond Preventing RAGE Activation in Diabetic Apolipoprotein E Knockout Mice
por: Watson, Anna M.D., et al.
Publicado: (2012)

Candesartan Cilexetil Improves Angiotensin II Type 2 Receptor–Mediated Neurite Outgrowth via the PI3K-Akt Pathway in Fructose-Induced Insulin-Resistant Rats
por: Hashikawa-Hobara, Narumi, et al.
Publicado: (2012)

Hyperhexosemia-Induced Retinal Vascular Pathology in a Novel Primate Model of Diabetic Retinopathy
por: Chronopoulos, Argyrios, et al.
Publicado: (2015)

Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes
por: Soro-Paavonen, Aino, et al.
Publicado: (2008)

Glycolytic overload-driven dysfunction of periodontal ligament fibroblasts in high glucose concentration, corrected by glyoxalase 1 inducer
por: Ashour, Amal, et al.
Publicado: (2020)

Plasma Kallikrein Mediates Retinal Vascular Dysfunction and Induces Retinal Thickening in Diabetic Rats
por: Clermont, Allen, et al.
Publicado: (2011)

Novel Detection and Restorative Levodopa Treatment for Preclinical Diabetic Retinopathy
por: Motz, Cara T., et al.
Publicado: (2020)

Aflibercept ameliorates retinal pericyte loss and restores perfusion in streptozotocin-induced diabetic mice
por: Seo, Eoi Jong, et al.
Publicado: (2020)

Dedifferentiation of Immortalized Human Podocytes in Response to Transforming Growth Factor-β: A Model for Diabetic Podocytopathy
por: Herman-Edelstein, Michal, et al.
Publicado: (2011)

Monosodium Urate Contributes to Retinal Inflammation and Progression of Diabetic Retinopathy
por: Thounaojam, Menaka C., et al.
Publicado: (2019)

Patrolling Monocytes Are Recruited and Activated by Diabetes to Protect Retinal Microvessels
por: Tecilazich, Francesco, et al.
Publicado: (2020)

Diabetes Disrupts the Response of Retinal Endothelial Cells to the Angiomodulator Lysophosphatidic Acid
por: Aranda, Jorge, et al.
Publicado: (2012)

Inhibition of Plasminogen Activator Inhibitor-1 Restores Skeletal Muscle Regeneration in Untreated Type 1 Diabetic Mice
por: Krause, Matthew P., et al.
Publicado: (2011)

Insulin Rescues Impaired Spermatogenesis via the Hypothalamic-Pituitary-Gonadal Axis in Akita Diabetic Mice and Restores Male Fertility
por: Schoeller, Erica L., et al.
Publicado: (2012)

Sarm1 Gene Deficiency Attenuates Diabetic Peripheral Neuropathy in Mice
por: Cheng, Yalan, et al.
Publicado: (2019)

REDD1 Ablation Attenuates the Development of Renal Complications in Diabetic Mice
por: Sunilkumar, Siddharth, et al.
Publicado: (2022)

The Unconventional Role of Acid Sphingomyelinase in Regulation of Retinal Microangiopathy in Diabetic Human and Animal Models
por: Opreanu, Madalina, et al.
Publicado: (2011)

Müller Cell-Derived VEGF Is Essential for Diabetes-Induced Retinal Inflammation and Vascular Leakage
por: Wang, Juanjuan, et al.
Publicado: (2010)

mTORC1-Independent Reduction of Retinal Protein Synthesis in Type 1 Diabetes
por: Fort, Patrice E., et al.
Publicado: (2014)

Interphotoreceptor Retinol-Binding Protein Ameliorates Diabetes-Induced Retinal Dysfunction and Neurodegeneration Through Rhodopsin
por: Chen, Jianglei, et al.
Publicado: (2021)

Müller Glial Expression of REDD1 Is Required for Retinal Neurodegeneration and Visual Dysfunction in Diabetic Mice
por: Miller, William P., et al.
Publicado: (2022)

Hydrogen Sulfide Improves Wound Healing via Restoration of Endothelial Progenitor Cell Functions and Activation of Angiopoietin-1 in Type 2 Diabetes
por: Liu, Fang, et al.
Publicado: (2014)

Severe Hypoglycemia–Induced Fatal Cardiac Arrhythmias Are Augmented by Diabetes and Attenuated by Recurrent Hypoglycemia
por: Reno, Candace M., et al.
Publicado: (2017)

Neural Retinal Disorganization as a Robust Marker of Visual Acuity in Current and Resolved Diabetic Macular Edema
por: Sun, Jennifer K., et al.
Publicado: (2015)

miR-200a Prevents Renal Fibrogenesis Through Repression of TGF-β2 Expression
por: Wang, Bo, et al.
Publicado: (2011)

Calcium Dobesilate Inhibits the Alterations in Tight Junction Proteins and Leukocyte Adhesion to Retinal Endothelial Cells Induced by Diabetes
por: Leal, Ermelindo C., et al.
Publicado: (2010)

Antiatherosclerotic and Renoprotective Effects of Ebselen in the Diabetic Apolipoprotein E/GPx1-Double Knockout Mouse
por: Chew, Phyllis, et al.
Publicado: (2010)

Increased Expression and Activity of 12-Lipoxygenase in Oxygen-Induced Ischemic Retinopathy and Proliferative Diabetic Retinopathy: Implications in Retinal Neovascularization
por: Al-Shabrawey, Mohamed, et al.
Publicado: (2011)

Human Apolipoprotein(a) Kringle V Inhibits Ischemia-Induced Retinal Neovascularization via Suppression of Fibronectin-Mediated Angiogenesis
por: Lim, Yangmi, et al.
Publicado: (2012)

Topical Prostaglandin E Analog Restores Defective Dendritic Cell–Mediated Th17 Host Defense Against Methicillin-Resistant Staphylococcus Aureus in the Skin of Diabetic Mice
por: Dejani, Naiara N., et al.
Publicado: (2016)

Heterogeneous Nuclear Ribonucleoprotein F Suppresses Angiotensinogen Gene Expression and Attenuates Hypertension and Kidney Injury in Diabetic Mice
por: Lo, Chao-Sheng, et al.
Publicado: (2012)

Early-Outgrowth Bone Marrow Cells Attenuate Renal Injury and Dysfunction via an Antioxidant Effect in a Mouse Model of Type 2 Diabetes
por: Zhang, Yanling, et al.
Publicado: (2012)

CD40 in Retinal Müller Cells Induces P2X(7)-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy
por: Portillo, Jose-Andres C., et al.
Publicado: (2017)

Improvement of Retinal Vascular Injury in Diabetic Rats by Statins Is Associated With the Inhibition of Mitochondrial Reactive Oxygen Species Pathway Mediated by Peroxisome Proliferator–Activated Receptor γ Coactivator 1α
por: Zheng, Zhi, et al.
Publicado: (2010)

Arginase-2 Mediates Diabetic Renal Injury
por: Morris, Sidney M., et al.
Publicado: (2011)

Longitudinal Assessment of Neuroanatomical and Cognitive Differences in Young Children With Type 1 Diabetes: Association With Hyperglycemia
por: Mauras, Nelly, et al.
Publicado: (2015)

E-Cadherin Expression Is Regulated by miR-192/215 by a Mechanism That Is Independent of the Profibrotic Effects of Transforming Growth Factor-β
por: Wang, Bo, et al.
Publicado: (2010)

Retinal Arteriolar Dilation Predicts Retinopathy in Adolescents With Type 1 Diabetes
por: Cheung, Ning, et al.
Publicado: (2008)

Inhibition of Methylglyoxal-Mediated Protein Modification in Glyoxalase I Overexpressing Mouse Lenses
por: Gangadhariah, Mahesha H., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_g9ebe6lhm3ojqltp8d4q1llqbq