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Effect of HLA Class I and Class II Alleles on Progression From Autoantibody Positivity to Overt Type 1 Diabetes in Children With Risk-Associated Class II Genotypes

OBJECTIVE: Class II alleles define the main HLA effect on type 1 diabetes, but there is an independent effect of certain class I alleles. Class II and class I molecules are differently involved in the initiation and effector phases of the immune response, suggesting that class I alleles would be imp...

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Detalles Bibliográficos
Autores principales:	Lipponen, Kati, Gombos, Zsofia, Kiviniemi, Minna, Siljander, Heli, Lempainen, Johanna, Hermann, Robert, Veijola, Riitta, Simell, Olli, Knip, Mikael, Ilonen, Jorma
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992790/ https://www.ncbi.nlm.nih.gov/pubmed/20739684 http://dx.doi.org/10.2337/db10-0167

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