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Troxipide in the Management of Gastritis: A Randomized Comparative Trial in General Practice

Background. A trial of empirical acid-suppressive therapy is the usual practice for most patients with symptoms of gastritis in primary care. Aim. To assess the relative efficacy of Troxipide and Ranitidine in patients with endoscopic gastritis over a four-week period. Methods. In all, 142 patients...

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Autores principales: Dewan, Bhupesh, Balasubramanian, Aarthi
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992815/
https://www.ncbi.nlm.nih.gov/pubmed/21127703
http://dx.doi.org/10.1155/2010/758397
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author Dewan, Bhupesh
Balasubramanian, Aarthi
author_facet Dewan, Bhupesh
Balasubramanian, Aarthi
author_sort Dewan, Bhupesh
collection PubMed
description Background. A trial of empirical acid-suppressive therapy is the usual practice for most patients with symptoms of gastritis in primary care. Aim. To assess the relative efficacy of Troxipide and Ranitidine in patients with endoscopic gastritis over a four-week period. Methods. In all, 142 patients were randomized to Troxipide (100 mg tid) or Ranitidine (150 mg bid) for a period of four weeks. The severity of the signs of endoscopic gastritis at baseline and week 4 using a four-point scale and the subjective symptom severity at baseline and week 2 & week 4 using a Visual analog scale (VAS) were documented. Results. Troxipide was found to be superior to Ranitidine for both, the complete resolution and improvement of endoscopic gastritis. Higher proportion of patients showed complete healing of erosions (88.14%), oozing (96.77%), and edema (93.88%) with Troxipide as compared to Ranitidine (P < .01). Patients receiving Troxipide also showed a greater improvement in the VAS scores for abdominal pain, bloating, and heartburn (P < .01). Both the drugs were found to be well tolerated. Conclusion. In patients with endoscopic gastritis, Troxipide, with its superior rate of improvement, resolution of signs, and subjective clinical symptoms, can be considered as an alternative to the commonly used antisecretory agents.
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spelling pubmed-29928152010-12-02 Troxipide in the Management of Gastritis: A Randomized Comparative Trial in General Practice Dewan, Bhupesh Balasubramanian, Aarthi Gastroenterol Res Pract Clinical Study Background. A trial of empirical acid-suppressive therapy is the usual practice for most patients with symptoms of gastritis in primary care. Aim. To assess the relative efficacy of Troxipide and Ranitidine in patients with endoscopic gastritis over a four-week period. Methods. In all, 142 patients were randomized to Troxipide (100 mg tid) or Ranitidine (150 mg bid) for a period of four weeks. The severity of the signs of endoscopic gastritis at baseline and week 4 using a four-point scale and the subjective symptom severity at baseline and week 2 & week 4 using a Visual analog scale (VAS) were documented. Results. Troxipide was found to be superior to Ranitidine for both, the complete resolution and improvement of endoscopic gastritis. Higher proportion of patients showed complete healing of erosions (88.14%), oozing (96.77%), and edema (93.88%) with Troxipide as compared to Ranitidine (P < .01). Patients receiving Troxipide also showed a greater improvement in the VAS scores for abdominal pain, bloating, and heartburn (P < .01). Both the drugs were found to be well tolerated. Conclusion. In patients with endoscopic gastritis, Troxipide, with its superior rate of improvement, resolution of signs, and subjective clinical symptoms, can be considered as an alternative to the commonly used antisecretory agents. Hindawi Publishing Corporation 2010 2010-11-25 /pmc/articles/PMC2992815/ /pubmed/21127703 http://dx.doi.org/10.1155/2010/758397 Text en Copyright © 2010 B. Dewan and A. Balasubramanian. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Dewan, Bhupesh
Balasubramanian, Aarthi
Troxipide in the Management of Gastritis: A Randomized Comparative Trial in General Practice
title Troxipide in the Management of Gastritis: A Randomized Comparative Trial in General Practice
title_full Troxipide in the Management of Gastritis: A Randomized Comparative Trial in General Practice
title_fullStr Troxipide in the Management of Gastritis: A Randomized Comparative Trial in General Practice
title_full_unstemmed Troxipide in the Management of Gastritis: A Randomized Comparative Trial in General Practice
title_short Troxipide in the Management of Gastritis: A Randomized Comparative Trial in General Practice
title_sort troxipide in the management of gastritis: a randomized comparative trial in general practice
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992815/
https://www.ncbi.nlm.nih.gov/pubmed/21127703
http://dx.doi.org/10.1155/2010/758397
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