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Antimicrobial Peptides in Gastrointestinal Inflammation
Acute and chronic inflammations of mucosal surfaces are complex events in which the effector mechanisms of innate and adaptive immune systems interact with pathogenic and commensal bacteria. The role of constitutive and inducible antimicrobial peptides in intestinal inflammation has been investigate...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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SAGE-Hindawi Access to Research
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992817/ https://www.ncbi.nlm.nih.gov/pubmed/21151692 http://dx.doi.org/10.4061/2010/910283 |
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author | Jäger, Simon Stange, Eduard F. Wehkamp, Jan |
author_facet | Jäger, Simon Stange, Eduard F. Wehkamp, Jan |
author_sort | Jäger, Simon |
collection | PubMed |
description | Acute and chronic inflammations of mucosal surfaces are complex events in which the effector mechanisms of innate and adaptive immune systems interact with pathogenic and commensal bacteria. The role of constitutive and inducible antimicrobial peptides in intestinal inflammation has been investigated thoroughly over the recent years, and their involvement in various disease states is expanded ever more. Especially in the intestines, a critical balance between luminal bacteria and the antimicrobial peptides is essential, and a breakdown in barrier function by impaired production of defensins is already implicated in Crohn's disease. In this paper, we focus on the role of antimicrobial peptides in inflammatory processes along the gastrointestinal tract, while considering the resident and pathogenic flora encountered at the specific sites. The role of antimicrobial peptides in the primary events of inflammatory bowel diseases receives special attention. |
format | Text |
id | pubmed-2992817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-29928172010-12-13 Antimicrobial Peptides in Gastrointestinal Inflammation Jäger, Simon Stange, Eduard F. Wehkamp, Jan Int J Inflam Review Article Acute and chronic inflammations of mucosal surfaces are complex events in which the effector mechanisms of innate and adaptive immune systems interact with pathogenic and commensal bacteria. The role of constitutive and inducible antimicrobial peptides in intestinal inflammation has been investigated thoroughly over the recent years, and their involvement in various disease states is expanded ever more. Especially in the intestines, a critical balance between luminal bacteria and the antimicrobial peptides is essential, and a breakdown in barrier function by impaired production of defensins is already implicated in Crohn's disease. In this paper, we focus on the role of antimicrobial peptides in inflammatory processes along the gastrointestinal tract, while considering the resident and pathogenic flora encountered at the specific sites. The role of antimicrobial peptides in the primary events of inflammatory bowel diseases receives special attention. SAGE-Hindawi Access to Research 2010-11-25 /pmc/articles/PMC2992817/ /pubmed/21151692 http://dx.doi.org/10.4061/2010/910283 Text en Copyright © 2010 Simon Jäger et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Jäger, Simon Stange, Eduard F. Wehkamp, Jan Antimicrobial Peptides in Gastrointestinal Inflammation |
title | Antimicrobial Peptides in Gastrointestinal Inflammation |
title_full | Antimicrobial Peptides in Gastrointestinal Inflammation |
title_fullStr | Antimicrobial Peptides in Gastrointestinal Inflammation |
title_full_unstemmed | Antimicrobial Peptides in Gastrointestinal Inflammation |
title_short | Antimicrobial Peptides in Gastrointestinal Inflammation |
title_sort | antimicrobial peptides in gastrointestinal inflammation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992817/ https://www.ncbi.nlm.nih.gov/pubmed/21151692 http://dx.doi.org/10.4061/2010/910283 |
work_keys_str_mv | AT jagersimon antimicrobialpeptidesingastrointestinalinflammation AT stangeeduardf antimicrobialpeptidesingastrointestinalinflammation AT wehkampjan antimicrobialpeptidesingastrointestinalinflammation |