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Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis

Patients with chronic hypergastrinemia due to chronic atrophic gastritis or gastrinomas have an increased risk of developing gastric malignancy, and it has been questioned whether also patients with hypergastrinemia caused by long-term use of acid inhibiting drugs are at risk. Gastric carcinogenesis...

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Autores principales: Fossmark, Reidar, Qvigstad, Gunnar, Martinsen, Tom Chr., Hauso, Øyvind, Waldum, Helge L.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992820/
https://www.ncbi.nlm.nih.gov/pubmed/21127707
http://dx.doi.org/10.1155/2011/975479
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author Fossmark, Reidar
Qvigstad, Gunnar
Martinsen, Tom Chr.
Hauso, Øyvind
Waldum, Helge L.
author_facet Fossmark, Reidar
Qvigstad, Gunnar
Martinsen, Tom Chr.
Hauso, Øyvind
Waldum, Helge L.
author_sort Fossmark, Reidar
collection PubMed
description Patients with chronic hypergastrinemia due to chronic atrophic gastritis or gastrinomas have an increased risk of developing gastric malignancy, and it has been questioned whether also patients with hypergastrinemia caused by long-term use of acid inhibiting drugs are at risk. Gastric carcinogenesis in humans is affected by numerous factors and progresses slowly over years. When using animal models with the possibility of intervention, a complex process can be dissected by studying the role of hypergastrinemia in carcinogenesis within a relatively short period of time. We have reviewed findings from relevant models where gastric changes in animal models of long-term hypergastrinemia have been investigated. In all species where long-term hypergastrinemia has been induced, there is an increased risk of gastric malignancy. There is evidence that hypergastrinemia is a common causative factor in carcinogenesis in the oxyntic mucosa, while other cofactors may vary in the different models.
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spelling pubmed-29928202010-12-02 Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis Fossmark, Reidar Qvigstad, Gunnar Martinsen, Tom Chr. Hauso, Øyvind Waldum, Helge L. J Biomed Biotechnol Review Article Patients with chronic hypergastrinemia due to chronic atrophic gastritis or gastrinomas have an increased risk of developing gastric malignancy, and it has been questioned whether also patients with hypergastrinemia caused by long-term use of acid inhibiting drugs are at risk. Gastric carcinogenesis in humans is affected by numerous factors and progresses slowly over years. When using animal models with the possibility of intervention, a complex process can be dissected by studying the role of hypergastrinemia in carcinogenesis within a relatively short period of time. We have reviewed findings from relevant models where gastric changes in animal models of long-term hypergastrinemia have been investigated. In all species where long-term hypergastrinemia has been induced, there is an increased risk of gastric malignancy. There is evidence that hypergastrinemia is a common causative factor in carcinogenesis in the oxyntic mucosa, while other cofactors may vary in the different models. Hindawi Publishing Corporation 2011 2010-11-24 /pmc/articles/PMC2992820/ /pubmed/21127707 http://dx.doi.org/10.1155/2011/975479 Text en Copyright © 2011 Reidar Fossmark et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Fossmark, Reidar
Qvigstad, Gunnar
Martinsen, Tom Chr.
Hauso, Øyvind
Waldum, Helge L.
Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis
title Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis
title_full Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis
title_fullStr Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis
title_full_unstemmed Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis
title_short Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis
title_sort animal models to study the role of long-term hypergastrinemia in gastric carcinogenesis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992820/
https://www.ncbi.nlm.nih.gov/pubmed/21127707
http://dx.doi.org/10.1155/2011/975479
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