Cargando…
Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis
Patients with chronic hypergastrinemia due to chronic atrophic gastritis or gastrinomas have an increased risk of developing gastric malignancy, and it has been questioned whether also patients with hypergastrinemia caused by long-term use of acid inhibiting drugs are at risk. Gastric carcinogenesis...
Autores principales: | , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992820/ https://www.ncbi.nlm.nih.gov/pubmed/21127707 http://dx.doi.org/10.1155/2011/975479 |
_version_ | 1782192784577396736 |
---|---|
author | Fossmark, Reidar Qvigstad, Gunnar Martinsen, Tom Chr. Hauso, Øyvind Waldum, Helge L. |
author_facet | Fossmark, Reidar Qvigstad, Gunnar Martinsen, Tom Chr. Hauso, Øyvind Waldum, Helge L. |
author_sort | Fossmark, Reidar |
collection | PubMed |
description | Patients with chronic hypergastrinemia due to chronic atrophic gastritis or gastrinomas have an increased risk of developing gastric malignancy, and it has been questioned whether also patients with hypergastrinemia caused by long-term use of acid inhibiting drugs are at risk. Gastric carcinogenesis in humans is affected by numerous factors and progresses slowly over years. When using animal models with the possibility of intervention, a complex process can be dissected by studying the role of hypergastrinemia in carcinogenesis within a relatively short period of time. We have reviewed findings from relevant models where gastric changes in animal models of long-term hypergastrinemia have been investigated. In all species where long-term hypergastrinemia has been induced, there is an increased risk of gastric malignancy. There is evidence that hypergastrinemia is a common causative factor in carcinogenesis in the oxyntic mucosa, while other cofactors may vary in the different models. |
format | Text |
id | pubmed-2992820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-29928202010-12-02 Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis Fossmark, Reidar Qvigstad, Gunnar Martinsen, Tom Chr. Hauso, Øyvind Waldum, Helge L. J Biomed Biotechnol Review Article Patients with chronic hypergastrinemia due to chronic atrophic gastritis or gastrinomas have an increased risk of developing gastric malignancy, and it has been questioned whether also patients with hypergastrinemia caused by long-term use of acid inhibiting drugs are at risk. Gastric carcinogenesis in humans is affected by numerous factors and progresses slowly over years. When using animal models with the possibility of intervention, a complex process can be dissected by studying the role of hypergastrinemia in carcinogenesis within a relatively short period of time. We have reviewed findings from relevant models where gastric changes in animal models of long-term hypergastrinemia have been investigated. In all species where long-term hypergastrinemia has been induced, there is an increased risk of gastric malignancy. There is evidence that hypergastrinemia is a common causative factor in carcinogenesis in the oxyntic mucosa, while other cofactors may vary in the different models. Hindawi Publishing Corporation 2011 2010-11-24 /pmc/articles/PMC2992820/ /pubmed/21127707 http://dx.doi.org/10.1155/2011/975479 Text en Copyright © 2011 Reidar Fossmark et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Fossmark, Reidar Qvigstad, Gunnar Martinsen, Tom Chr. Hauso, Øyvind Waldum, Helge L. Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis |
title | Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis |
title_full | Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis |
title_fullStr | Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis |
title_full_unstemmed | Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis |
title_short | Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis |
title_sort | animal models to study the role of long-term hypergastrinemia in gastric carcinogenesis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992820/ https://www.ncbi.nlm.nih.gov/pubmed/21127707 http://dx.doi.org/10.1155/2011/975479 |
work_keys_str_mv | AT fossmarkreidar animalmodelstostudytheroleoflongtermhypergastrinemiaingastriccarcinogenesis AT qvigstadgunnar animalmodelstostudytheroleoflongtermhypergastrinemiaingastriccarcinogenesis AT martinsentomchr animalmodelstostudytheroleoflongtermhypergastrinemiaingastriccarcinogenesis AT hausoøyvind animalmodelstostudytheroleoflongtermhypergastrinemiaingastriccarcinogenesis AT waldumhelgel animalmodelstostudytheroleoflongtermhypergastrinemiaingastriccarcinogenesis |