B7-H3 and Its Role in Antitumor Immunity

B7-H3 is one of the most recently identified members of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T-cell response. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumo...

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Detalles Bibliográficos
Autores principales: Loos, Martin, Hedderich, Dennis M., Friess, Helmut, Kleeff, Jörg
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993024/
https://www.ncbi.nlm.nih.gov/pubmed/21127709
http://dx.doi.org/10.1155/2010/683875
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author Loos, Martin
Hedderich, Dennis M.
Friess, Helmut
Kleeff, Jörg
author_facet Loos, Martin
Hedderich, Dennis M.
Friess, Helmut
Kleeff, Jörg
author_sort Loos, Martin
collection PubMed
description B7-H3 is one of the most recently identified members of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T-cell response. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity. However, its precise physiologic role is still elusive, because both stimulatory and inhibitory capacities have been demonstrated. This paper summarizes the available data on B7-H3 in the regulation of T-cell response focusing on its potential role in antitumor immunity.
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spelling pubmed-29930242010-12-02 B7-H3 and Its Role in Antitumor Immunity Loos, Martin Hedderich, Dennis M. Friess, Helmut Kleeff, Jörg Clin Dev Immunol Review Article B7-H3 is one of the most recently identified members of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T-cell response. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity. However, its precise physiologic role is still elusive, because both stimulatory and inhibitory capacities have been demonstrated. This paper summarizes the available data on B7-H3 in the regulation of T-cell response focusing on its potential role in antitumor immunity. Hindawi Publishing Corporation 2010 2010-11-28 /pmc/articles/PMC2993024/ /pubmed/21127709 http://dx.doi.org/10.1155/2010/683875 Text en Copyright © 2010 Martin Loos et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Loos, Martin
Hedderich, Dennis M.
Friess, Helmut
Kleeff, Jörg
B7-H3 and Its Role in Antitumor Immunity
title B7-H3 and Its Role in Antitumor Immunity
title_full B7-H3 and Its Role in Antitumor Immunity
title_fullStr B7-H3 and Its Role in Antitumor Immunity
title_full_unstemmed B7-H3 and Its Role in Antitumor Immunity
title_short B7-H3 and Its Role in Antitumor Immunity
title_sort b7-h3 and its role in antitumor immunity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993024/
https://www.ncbi.nlm.nih.gov/pubmed/21127709
http://dx.doi.org/10.1155/2010/683875
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AT friesshelmut b7h3anditsroleinantitumorimmunity
AT kleeffjorg b7h3anditsroleinantitumorimmunity

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