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Evidence for Activation of Toll-Like Receptor and Receptor for Advanced Glycation End Products in Preterm Birth

Objective. Individuals with inflammation have a myriad of pregnancy aberrations including increasing their preterm birth risk. Toll-like receptors (TLRs) and receptor for advanced glycation end products (RAGE) and their ligands were all found to play a key role in inflammation. In the present study,...

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Autores principales: Noguchi, Taketoshi, Sado, Toshiyuki, Naruse, Katsuhiko, Shigetomi, Hiroshi, Onogi, Akira, Haruta, Shoji, Kawaguchi, Ryuji, Nagai, Akira, Tanase, Yasuhito, Yoshida, Shozo, Kitanaka, Takashi, Oi, Hidekazu, Kobayashi, Hiroshi
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993025/
https://www.ncbi.nlm.nih.gov/pubmed/21127710
http://dx.doi.org/10.1155/2010/490406
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author Noguchi, Taketoshi
Sado, Toshiyuki
Naruse, Katsuhiko
Shigetomi, Hiroshi
Onogi, Akira
Haruta, Shoji
Kawaguchi, Ryuji
Nagai, Akira
Tanase, Yasuhito
Yoshida, Shozo
Kitanaka, Takashi
Oi, Hidekazu
Kobayashi, Hiroshi
author_facet Noguchi, Taketoshi
Sado, Toshiyuki
Naruse, Katsuhiko
Shigetomi, Hiroshi
Onogi, Akira
Haruta, Shoji
Kawaguchi, Ryuji
Nagai, Akira
Tanase, Yasuhito
Yoshida, Shozo
Kitanaka, Takashi
Oi, Hidekazu
Kobayashi, Hiroshi
author_sort Noguchi, Taketoshi
collection PubMed
description Objective. Individuals with inflammation have a myriad of pregnancy aberrations including increasing their preterm birth risk. Toll-like receptors (TLRs) and receptor for advanced glycation end products (RAGE) and their ligands were all found to play a key role in inflammation. In the present study, we reviewed TLR and RAGE expression, their ligands, and signaling in preterm birth. Research Design and Methods. A systematic search was performed in the electronic databases PubMed and ScienceDirect up to July 2010, combining the keywords “preterm birth,” “TLR”, “RAGE”, “danger signal”, “alarmin”, “genomewide,” “microarray,” and “proteomics” with specific expression profiles of genes and proteins. Results. This paper provides data on TLR and RAGE levels and critical downstream signaling events including NF-kappaB-dependent proinflammatory cytokine expression in preterm birth. About half of the genes and proteins specifically present in preterm birth have the properties of endogenous ligands “alarmin” for receptor activation. The interactions between the TLR-mediated acute inflammation and RAGE-mediated chronic inflammation have clear implications for preterm birth via the TLR and RAGE system, which may be acting collectively. Conclusions. TLR and RAGE expression and their ligands, signaling, and functional activation are increased in preterm birth and may contribute to the proinflammatory state.
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spelling pubmed-29930252010-12-02 Evidence for Activation of Toll-Like Receptor and Receptor for Advanced Glycation End Products in Preterm Birth Noguchi, Taketoshi Sado, Toshiyuki Naruse, Katsuhiko Shigetomi, Hiroshi Onogi, Akira Haruta, Shoji Kawaguchi, Ryuji Nagai, Akira Tanase, Yasuhito Yoshida, Shozo Kitanaka, Takashi Oi, Hidekazu Kobayashi, Hiroshi Mediators Inflamm Review Article Objective. Individuals with inflammation have a myriad of pregnancy aberrations including increasing their preterm birth risk. Toll-like receptors (TLRs) and receptor for advanced glycation end products (RAGE) and their ligands were all found to play a key role in inflammation. In the present study, we reviewed TLR and RAGE expression, their ligands, and signaling in preterm birth. Research Design and Methods. A systematic search was performed in the electronic databases PubMed and ScienceDirect up to July 2010, combining the keywords “preterm birth,” “TLR”, “RAGE”, “danger signal”, “alarmin”, “genomewide,” “microarray,” and “proteomics” with specific expression profiles of genes and proteins. Results. This paper provides data on TLR and RAGE levels and critical downstream signaling events including NF-kappaB-dependent proinflammatory cytokine expression in preterm birth. About half of the genes and proteins specifically present in preterm birth have the properties of endogenous ligands “alarmin” for receptor activation. The interactions between the TLR-mediated acute inflammation and RAGE-mediated chronic inflammation have clear implications for preterm birth via the TLR and RAGE system, which may be acting collectively. Conclusions. TLR and RAGE expression and their ligands, signaling, and functional activation are increased in preterm birth and may contribute to the proinflammatory state. Hindawi Publishing Corporation 2010 2010-11-28 /pmc/articles/PMC2993025/ /pubmed/21127710 http://dx.doi.org/10.1155/2010/490406 Text en Copyright © 2010 Taketoshi Noguchi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Noguchi, Taketoshi
Sado, Toshiyuki
Naruse, Katsuhiko
Shigetomi, Hiroshi
Onogi, Akira
Haruta, Shoji
Kawaguchi, Ryuji
Nagai, Akira
Tanase, Yasuhito
Yoshida, Shozo
Kitanaka, Takashi
Oi, Hidekazu
Kobayashi, Hiroshi
Evidence for Activation of Toll-Like Receptor and Receptor for Advanced Glycation End Products in Preterm Birth
title Evidence for Activation of Toll-Like Receptor and Receptor for Advanced Glycation End Products in Preterm Birth
title_full Evidence for Activation of Toll-Like Receptor and Receptor for Advanced Glycation End Products in Preterm Birth
title_fullStr Evidence for Activation of Toll-Like Receptor and Receptor for Advanced Glycation End Products in Preterm Birth
title_full_unstemmed Evidence for Activation of Toll-Like Receptor and Receptor for Advanced Glycation End Products in Preterm Birth
title_short Evidence for Activation of Toll-Like Receptor and Receptor for Advanced Glycation End Products in Preterm Birth
title_sort evidence for activation of toll-like receptor and receptor for advanced glycation end products in preterm birth
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993025/
https://www.ncbi.nlm.nih.gov/pubmed/21127710
http://dx.doi.org/10.1155/2010/490406
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