Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2

Two compounds known to covalently bind to DNA after their activation with cytochromes P450 (CYPs), carcinogenic benzo(a)pyrene (BaP) and an antineoplastic agent ellipticine, were investigated for their potential to induce CYP and NADPH:CYP reductase (POR) enzymes in rodent livers, the main target or...

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Detalles Bibliográficos
Autores principales: Aimová, Dagmar, Poljaková, Jitka, Kotrbová, Věra, Moserová, Michaela, Frei, Eva, Arlt, Volker M., Stiborová, Marie
Formato: Texto
Lenguaje:English
Publicado: Slovak Toxicology Society SETOX 2008
Materias:
A Comparative Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993483/
https://www.ncbi.nlm.nih.gov/pubmed/21218107
http://dx.doi.org/10.2478/V10102-010-0033-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993483/
https://www.ncbi.nlm.nih.gov/pubmed/21218107
http://dx.doi.org/10.2478/V10102-010-0033-z

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