Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone

BACKGROUND: Giant cell tumors (GCTs) of bone are primary benign bone tumors that are characterized by a high number of osteoclast-like multinuclear giant cells (MNCs). Recent studies suggest that the spindle-shaped stromal cells in GCTs are tumor cells, while monocyte-like cells and MNCs are reactiv...

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Detalles Bibliográficos
Autores principales: Matsumoto, Yoshihiro, Okada, Yuko, Fukushi, Jun-ichi, Kamura, Satoshi, Fujiwara, Toshifumi, Iida, Keiichiro, Koga, Mihoko, Matsuda, Shuichi, Harimaya, Katsumi, Sakamoto, Akio, Iwamoto, Yukihide
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993664/
https://www.ncbi.nlm.nih.gov/pubmed/21062426
http://dx.doi.org/10.1186/1749-799X-5-85

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