The bridge helix coordinates movements of modules in RNA polymerase

The RNA polymerase 'bridge helix' is a metastable α-helix that spans the leading edge of the enzyme active-site cleft. A new study published in BMC Biology reveals surprising tolerance to helix-disrupting changes in a region previously thought crucial for translocation, and suggests roles...

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Detalles Bibliográficos
Autores principales: Hein, Pyae P, Landick, Robert
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993669/
https://www.ncbi.nlm.nih.gov/pubmed/21114873
http://dx.doi.org/10.1186/1741-7007-8-141
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author Hein, Pyae P
Landick, Robert
author_facet Hein, Pyae P
Landick, Robert
author_sort Hein, Pyae P
collection PubMed
description The RNA polymerase 'bridge helix' is a metastable α-helix that spans the leading edge of the enzyme active-site cleft. A new study published in BMC Biology reveals surprising tolerance to helix-disrupting changes in a region previously thought crucial for translocation, and suggests roles for two hinge-like segments of the bridge helix in coordinating modules that move during the nucleotide-addition cycle. See Research article: http://www.biomedcentral.com/1741-7007/8/134
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spelling pubmed-29936692010-11-30 The bridge helix coordinates movements of modules in RNA polymerase Hein, Pyae P Landick, Robert BMC Biol Commentary The RNA polymerase 'bridge helix' is a metastable α-helix that spans the leading edge of the enzyme active-site cleft. A new study published in BMC Biology reveals surprising tolerance to helix-disrupting changes in a region previously thought crucial for translocation, and suggests roles for two hinge-like segments of the bridge helix in coordinating modules that move during the nucleotide-addition cycle. See Research article: http://www.biomedcentral.com/1741-7007/8/134 BioMed Central 2010-11-29 /pmc/articles/PMC2993669/ /pubmed/21114873 http://dx.doi.org/10.1186/1741-7007-8-141 Text en Copyright ©2010 Hein and Landick; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Hein, Pyae P
Landick, Robert
The bridge helix coordinates movements of modules in RNA polymerase
title The bridge helix coordinates movements of modules in RNA polymerase
title_full The bridge helix coordinates movements of modules in RNA polymerase
title_fullStr The bridge helix coordinates movements of modules in RNA polymerase
title_full_unstemmed The bridge helix coordinates movements of modules in RNA polymerase
title_short The bridge helix coordinates movements of modules in RNA polymerase
title_sort bridge helix coordinates movements of modules in rna polymerase
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993669/
https://www.ncbi.nlm.nih.gov/pubmed/21114873
http://dx.doi.org/10.1186/1741-7007-8-141
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