Arsenic-Induced SUMO-Dependent Recruitment of RNF4 into PML Nuclear Bodies

In acute promyelocytic leukemia (APL), the promyelocytic leukemia (PML) protein is fused to the retinoic acid receptor alpha (RAR). Arsenic is an effective treatment for this disease as it induces SUMO-dependent ubiquitin-mediated proteasomal degradation of the PML-RAR fusion protein. Here we analyz...

Descripción completa

Detalles Bibliográficos
Autores principales: Geoffroy, Marie-Claude, Jaffray, Ellis G., Walker, Katherine J., Hay, Ronald T.
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993750/
https://www.ncbi.nlm.nih.gov/pubmed/20943951
http://dx.doi.org/10.1091/mbc.E10-05-0449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993750/
https://www.ncbi.nlm.nih.gov/pubmed/20943951
http://dx.doi.org/10.1091/mbc.E10-05-0449

Ejemplares similares