P53 levels govern the choice between senescence and quiescence

The mechanism(s) by which p53 chooses between outcomes of senescence or quiescence has remained elusive. A paper published in the recent issue of Cell Cycle indicates that this decision may be determined by p53 levels and their ability to selectively down-regulate mTOR signaling.

Detalles Bibliográficos
Autor principal: Meek, David W.
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993792/
Descripción
Sumario:The mechanism(s) by which p53 chooses between outcomes of senescence or quiescence has remained elusive. A paper published in the recent issue of Cell Cycle indicates that this decision may be determined by p53 levels and their ability to selectively down-regulate mTOR signaling.

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