Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths

The epithelial-mesenchymal transition is involved in several physiological processes. However, it is also believed to contribute to cancer progression. Conversely, cellular senescence constitutes a failsafe program against cancer progression. Interestingly, EMT and senescence seem to cross paths, wi...

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Detalles Bibliográficos
Autores principales: Smit, Marjon A., Peeper, Daniel S.
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993803/
https://www.ncbi.nlm.nih.gov/pubmed/20975209
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author Smit, Marjon A.
Peeper, Daniel S.
author_facet Smit, Marjon A.
Peeper, Daniel S.
author_sort Smit, Marjon A.
collection PubMed
description The epithelial-mesenchymal transition is involved in several physiological processes. However, it is also believed to contribute to cancer progression. Conversely, cellular senescence constitutes a failsafe program against cancer progression. Interestingly, EMT and senescence seem to cross paths, with several factors playing dominant roles in both settings. Here, we describe recent observations that link these important cellular processes.
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spelling pubmed-29938032010-11-30 Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths Smit, Marjon A. Peeper, Daniel S. Aging (Albany NY) Research Perspective The epithelial-mesenchymal transition is involved in several physiological processes. However, it is also believed to contribute to cancer progression. Conversely, cellular senescence constitutes a failsafe program against cancer progression. Interestingly, EMT and senescence seem to cross paths, with several factors playing dominant roles in both settings. Here, we describe recent observations that link these important cellular processes. Impact Journals LLC 2010-10-17 /pmc/articles/PMC2993803/ /pubmed/20975209 Text en Copyright: © 2010 Smit and Peeper http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Perspective
Smit, Marjon A.
Peeper, Daniel S.
Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths
title Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths
title_full Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths
title_fullStr Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths
title_full_unstemmed Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths
title_short Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths
title_sort epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993803/
https://www.ncbi.nlm.nih.gov/pubmed/20975209
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