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Principles of sample size calculation
In most areas in life, it is difficult to work with populations and hence researchers work with samples. The calculation of the sample size needed depends on the data type and distribution. Elements include consideration of the alpha error, beta error, clinically meaningful difference, and the varia...
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993982/ https://www.ncbi.nlm.nih.gov/pubmed/20952836 http://dx.doi.org/10.4103/0301-4738.71692 |
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author | Gogtay, Nithya J |
author_facet | Gogtay, Nithya J |
author_sort | Gogtay, Nithya J |
collection | PubMed |
description | In most areas in life, it is difficult to work with populations and hence researchers work with samples. The calculation of the sample size needed depends on the data type and distribution. Elements include consideration of the alpha error, beta error, clinically meaningful difference, and the variability or standard deviation. The final number arrived at should be increased to include a safety margin and the dropout rate. Over and above this, sample size calculations must take into account all available data, funding, support facilities, and ethics of subjecting patients to research. |
format | Text |
id | pubmed-2993982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-29939822010-11-30 Principles of sample size calculation Gogtay, Nithya J Indian J Ophthalmol Research Methodology In most areas in life, it is difficult to work with populations and hence researchers work with samples. The calculation of the sample size needed depends on the data type and distribution. Elements include consideration of the alpha error, beta error, clinically meaningful difference, and the variability or standard deviation. The final number arrived at should be increased to include a safety margin and the dropout rate. Over and above this, sample size calculations must take into account all available data, funding, support facilities, and ethics of subjecting patients to research. Medknow Publications 2010 /pmc/articles/PMC2993982/ /pubmed/20952836 http://dx.doi.org/10.4103/0301-4738.71692 Text en © Indian Journal of Ophthalmology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Methodology Gogtay, Nithya J Principles of sample size calculation |
title | Principles of sample size calculation |
title_full | Principles of sample size calculation |
title_fullStr | Principles of sample size calculation |
title_full_unstemmed | Principles of sample size calculation |
title_short | Principles of sample size calculation |
title_sort | principles of sample size calculation |
topic | Research Methodology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993982/ https://www.ncbi.nlm.nih.gov/pubmed/20952836 http://dx.doi.org/10.4103/0301-4738.71692 |
work_keys_str_mv | AT gogtaynithyaj principlesofsamplesizecalculation |