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Clinical, Molecular, and Environmental Risk Factors for Hodgkin Lymphoma
Epidemiological studies suggest unique occurrence patterns of Hodgkin lymphoma (HL) worldwide. In most Western countries there is a clear bimodal age distribution with an early peak in young adults followed by a second peak in older adults, particularly among males. In the Middle East and Asia, HL i...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994062/ https://www.ncbi.nlm.nih.gov/pubmed/21127715 http://dx.doi.org/10.1155/2011/736261 |
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author | Maggioncalda, Alison Malik, Neha Shenoy, Pareen Smith, Melody Sinha, Rajni Flowers, Christopher R. |
author_facet | Maggioncalda, Alison Malik, Neha Shenoy, Pareen Smith, Melody Sinha, Rajni Flowers, Christopher R. |
author_sort | Maggioncalda, Alison |
collection | PubMed |
description | Epidemiological studies suggest unique occurrence patterns of Hodgkin lymphoma (HL) worldwide. In most Western countries there is a clear bimodal age distribution with an early peak in young adults followed by a second peak in older adults, particularly among males. In the Middle East and Asia, HL is more common in early childhood. There also are marked racial differences in the presentations of HL and HL subtypes, and particular single nucleotide polymorphisms (SNPs) have been identified as etiological factors suggesting that gene-gene and gene-environment interactions are involved. Personal health choices such as exercise and smoking may modify an individual's chances of developing HL. Numerous studies highlight the impact that exposure to Epstein-Barr virus and other environmental factors have on HL risk. Understanding the relative importance of each of these findings and their links to HL development and survival will help clinical researchers expand curative therapies and create preventative strategies for HL. |
format | Text |
id | pubmed-2994062 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-29940622010-12-02 Clinical, Molecular, and Environmental Risk Factors for Hodgkin Lymphoma Maggioncalda, Alison Malik, Neha Shenoy, Pareen Smith, Melody Sinha, Rajni Flowers, Christopher R. Adv Hematol Review Article Epidemiological studies suggest unique occurrence patterns of Hodgkin lymphoma (HL) worldwide. In most Western countries there is a clear bimodal age distribution with an early peak in young adults followed by a second peak in older adults, particularly among males. In the Middle East and Asia, HL is more common in early childhood. There also are marked racial differences in the presentations of HL and HL subtypes, and particular single nucleotide polymorphisms (SNPs) have been identified as etiological factors suggesting that gene-gene and gene-environment interactions are involved. Personal health choices such as exercise and smoking may modify an individual's chances of developing HL. Numerous studies highlight the impact that exposure to Epstein-Barr virus and other environmental factors have on HL risk. Understanding the relative importance of each of these findings and their links to HL development and survival will help clinical researchers expand curative therapies and create preventative strategies for HL. Hindawi Publishing Corporation 2011 2010-11-29 /pmc/articles/PMC2994062/ /pubmed/21127715 http://dx.doi.org/10.1155/2011/736261 Text en Copyright © 2011 Alison Maggioncalda et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Maggioncalda, Alison Malik, Neha Shenoy, Pareen Smith, Melody Sinha, Rajni Flowers, Christopher R. Clinical, Molecular, and Environmental Risk Factors for Hodgkin Lymphoma |
title | Clinical, Molecular, and Environmental Risk Factors for Hodgkin Lymphoma |
title_full | Clinical, Molecular, and Environmental Risk Factors for Hodgkin Lymphoma |
title_fullStr | Clinical, Molecular, and Environmental Risk Factors for Hodgkin Lymphoma |
title_full_unstemmed | Clinical, Molecular, and Environmental Risk Factors for Hodgkin Lymphoma |
title_short | Clinical, Molecular, and Environmental Risk Factors for Hodgkin Lymphoma |
title_sort | clinical, molecular, and environmental risk factors for hodgkin lymphoma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994062/ https://www.ncbi.nlm.nih.gov/pubmed/21127715 http://dx.doi.org/10.1155/2011/736261 |
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