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Clinical, Molecular, and Environmental Risk Factors for Hodgkin Lymphoma

Epidemiological studies suggest unique occurrence patterns of Hodgkin lymphoma (HL) worldwide. In most Western countries there is a clear bimodal age distribution with an early peak in young adults followed by a second peak in older adults, particularly among males. In the Middle East and Asia, HL i...

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Autores principales: Maggioncalda, Alison, Malik, Neha, Shenoy, Pareen, Smith, Melody, Sinha, Rajni, Flowers, Christopher R.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994062/
https://www.ncbi.nlm.nih.gov/pubmed/21127715
http://dx.doi.org/10.1155/2011/736261
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author Maggioncalda, Alison
Malik, Neha
Shenoy, Pareen
Smith, Melody
Sinha, Rajni
Flowers, Christopher R.
author_facet Maggioncalda, Alison
Malik, Neha
Shenoy, Pareen
Smith, Melody
Sinha, Rajni
Flowers, Christopher R.
author_sort Maggioncalda, Alison
collection PubMed
description Epidemiological studies suggest unique occurrence patterns of Hodgkin lymphoma (HL) worldwide. In most Western countries there is a clear bimodal age distribution with an early peak in young adults followed by a second peak in older adults, particularly among males. In the Middle East and Asia, HL is more common in early childhood. There also are marked racial differences in the presentations of HL and HL subtypes, and particular single nucleotide polymorphisms (SNPs) have been identified as etiological factors suggesting that gene-gene and gene-environment interactions are involved. Personal health choices such as exercise and smoking may modify an individual's chances of developing HL. Numerous studies highlight the impact that exposure to Epstein-Barr virus and other environmental factors have on HL risk. Understanding the relative importance of each of these findings and their links to HL development and survival will help clinical researchers expand curative therapies and create preventative strategies for HL.
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spelling pubmed-29940622010-12-02 Clinical, Molecular, and Environmental Risk Factors for Hodgkin Lymphoma Maggioncalda, Alison Malik, Neha Shenoy, Pareen Smith, Melody Sinha, Rajni Flowers, Christopher R. Adv Hematol Review Article Epidemiological studies suggest unique occurrence patterns of Hodgkin lymphoma (HL) worldwide. In most Western countries there is a clear bimodal age distribution with an early peak in young adults followed by a second peak in older adults, particularly among males. In the Middle East and Asia, HL is more common in early childhood. There also are marked racial differences in the presentations of HL and HL subtypes, and particular single nucleotide polymorphisms (SNPs) have been identified as etiological factors suggesting that gene-gene and gene-environment interactions are involved. Personal health choices such as exercise and smoking may modify an individual's chances of developing HL. Numerous studies highlight the impact that exposure to Epstein-Barr virus and other environmental factors have on HL risk. Understanding the relative importance of each of these findings and their links to HL development and survival will help clinical researchers expand curative therapies and create preventative strategies for HL. Hindawi Publishing Corporation 2011 2010-11-29 /pmc/articles/PMC2994062/ /pubmed/21127715 http://dx.doi.org/10.1155/2011/736261 Text en Copyright © 2011 Alison Maggioncalda et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Maggioncalda, Alison
Malik, Neha
Shenoy, Pareen
Smith, Melody
Sinha, Rajni
Flowers, Christopher R.
Clinical, Molecular, and Environmental Risk Factors for Hodgkin Lymphoma
title Clinical, Molecular, and Environmental Risk Factors for Hodgkin Lymphoma
title_full Clinical, Molecular, and Environmental Risk Factors for Hodgkin Lymphoma
title_fullStr Clinical, Molecular, and Environmental Risk Factors for Hodgkin Lymphoma
title_full_unstemmed Clinical, Molecular, and Environmental Risk Factors for Hodgkin Lymphoma
title_short Clinical, Molecular, and Environmental Risk Factors for Hodgkin Lymphoma
title_sort clinical, molecular, and environmental risk factors for hodgkin lymphoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994062/
https://www.ncbi.nlm.nih.gov/pubmed/21127715
http://dx.doi.org/10.1155/2011/736261
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