Sorafenib inhibits tumor growth and vascularization of rhabdomyosarcoma cells by blocking IGF-1R-mediated signaling

The growth of many soft tissue sarcomas is dependent on aberrant growth factor signaling, which promotes their proliferation and motility. With this in mind, we evaluated the effect of sorafenib, a receptor tyrosine kinase inhibitor, on cell growth and apoptosis in sarcoma cell lines of various hist...

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Detalles Bibliográficos
Autores principales: Maruwge, Wessen, D’Arcy, Pádraig, Folin, Annika, Brnjic, Slavica, Wejde, Johan, Davis, Anthony, Erlandsson, Fredrik, Bergh, Jonas, Brodin, Bertha
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994208/
https://www.ncbi.nlm.nih.gov/pubmed/21127754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994208/
https://www.ncbi.nlm.nih.gov/pubmed/21127754

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