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Relationship between arachidonic acid pathway and human renal cell carcinoma
Recent epidemiological studies and animal experiments have demonstrated that nonsteroidal antiinflammatory drugs (NSAIDs) reduce the incidence of colorectal carcinoma. Cyclooxygenase (COX) is the principal target of NSAIDs. COX is the first oxidase in the process of prostaglandin production from ara...
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Formato: | Texto |
Lenguaje: | English |
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Dove Medical Press
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994214/ https://www.ncbi.nlm.nih.gov/pubmed/21127751 |
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author | Matsuyama, Masahide Yoshimura, Rikio |
author_facet | Matsuyama, Masahide Yoshimura, Rikio |
author_sort | Matsuyama, Masahide |
collection | PubMed |
description | Recent epidemiological studies and animal experiments have demonstrated that nonsteroidal antiinflammatory drugs (NSAIDs) reduce the incidence of colorectal carcinoma. Cyclooxygenase (COX) is the principal target of NSAIDs. COX is the first oxidase in the process of prostaglandin production from arachidonic acid. COX enzyme may be involved in the initiation and/or the promotion of carcinogenesis due to NSAIDs inhibition of COX. Lipoxygenase (LOX) is also an initial enzyme in the pathway for producing leukotrienes from arachidonic acid. Similar to COX, LOX enzyme may also be involved in the initiation and/or promotion of carcinogenesis. Peroxisome proliferator activator-receptor (PPAR)-γ is a ligand-activated transcriptional factor belonging to the steroid receptor superfamily. PPAR-γ plays a role in both adipocyte differentiation and carcinogenesis. PPAR-γ is one target for cell growth modulation of NSAIDs. In this review, we report the expression of COX-2, LOX and PPAR-γ in human renal cell carcinoma tissues as well as the effects of COX-2 and LOX inhibitors and PPAR-γ ligand. |
format | Text |
id | pubmed-2994214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-29942142010-12-02 Relationship between arachidonic acid pathway and human renal cell carcinoma Matsuyama, Masahide Yoshimura, Rikio Onco Targets Ther Review Recent epidemiological studies and animal experiments have demonstrated that nonsteroidal antiinflammatory drugs (NSAIDs) reduce the incidence of colorectal carcinoma. Cyclooxygenase (COX) is the principal target of NSAIDs. COX is the first oxidase in the process of prostaglandin production from arachidonic acid. COX enzyme may be involved in the initiation and/or the promotion of carcinogenesis due to NSAIDs inhibition of COX. Lipoxygenase (LOX) is also an initial enzyme in the pathway for producing leukotrienes from arachidonic acid. Similar to COX, LOX enzyme may also be involved in the initiation and/or promotion of carcinogenesis. Peroxisome proliferator activator-receptor (PPAR)-γ is a ligand-activated transcriptional factor belonging to the steroid receptor superfamily. PPAR-γ plays a role in both adipocyte differentiation and carcinogenesis. PPAR-γ is one target for cell growth modulation of NSAIDs. In this review, we report the expression of COX-2, LOX and PPAR-γ in human renal cell carcinoma tissues as well as the effects of COX-2 and LOX inhibitors and PPAR-γ ligand. Dove Medical Press 2008-10-01 /pmc/articles/PMC2994214/ /pubmed/21127751 Text en © 2008 Matsuyama and Yoshimura, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Review Matsuyama, Masahide Yoshimura, Rikio Relationship between arachidonic acid pathway and human renal cell carcinoma |
title | Relationship between arachidonic acid pathway and human renal cell carcinoma |
title_full | Relationship between arachidonic acid pathway and human renal cell carcinoma |
title_fullStr | Relationship between arachidonic acid pathway and human renal cell carcinoma |
title_full_unstemmed | Relationship between arachidonic acid pathway and human renal cell carcinoma |
title_short | Relationship between arachidonic acid pathway and human renal cell carcinoma |
title_sort | relationship between arachidonic acid pathway and human renal cell carcinoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994214/ https://www.ncbi.nlm.nih.gov/pubmed/21127751 |
work_keys_str_mv | AT matsuyamamasahide relationshipbetweenarachidonicacidpathwayandhumanrenalcellcarcinoma AT yoshimurarikio relationshipbetweenarachidonicacidpathwayandhumanrenalcellcarcinoma |