Maternal vitamin and iron supplementation and risk of infant leukaemia: a report from the Children's Oncology Group

BACKGROUND: Prenatal supplementation has been inversely associated with childhood, but not with infant, leukaemia. METHODS: Mothers of 443 cases of infant leukaemia diagnosed during 1996–2006 and 324 frequency-matched controls completed interviews. Associations were evaluated by unconditional logist...

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Detalles Bibliográficos
Autores principales: Linabery, A M, Puumala, S E, Hilden, J M, Davies, S M, Heerema, N A, Roesler, M A, Ross, J A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994226/
https://www.ncbi.nlm.nih.gov/pubmed/20978510
http://dx.doi.org/10.1038/sj.bjc.6605957
Descripción
Sumario:BACKGROUND: Prenatal supplementation has been inversely associated with childhood, but not with infant, leukaemia. METHODS: Mothers of 443 cases of infant leukaemia diagnosed during 1996–2006 and 324 frequency-matched controls completed interviews. Associations were evaluated by unconditional logistic regression. RESULTS: We observed no associations between prenatal vitamin (odds ratio (OR)=0.79, 95% confidence interval (CI): 0.44–1.42) or iron supplementation (OR=1.07, 95% CI: 0.75–1.52) and infant leukaemia after adjustment for race/ethnicity and income. Similar results were observed for leukaemia subtypes analysed separately. CONCLUSION: The observed null associations may be attributable to high supplementation rates and/or national fortification programmes.

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