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Validation of structural and functional lesions of diabetic retinopathy in mice

Diabetic retinopathy is a serious long-term complication of diabetes mellitus. There is considerable interest in using mouse models, which can be genetically modified, to understand how retinopathy develops and can be inhibited. Not all retinal lesions that develop in diabetic patients have been rep...

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Autores principales: Kern, T.S., Tang, J., Berkowitz, B.A.
Formato: Texto
Lenguaje:English
Publicado: Molecular Vision 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994360/
https://www.ncbi.nlm.nih.gov/pubmed/21139688
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author Kern, T.S.
Tang, J.
Berkowitz, B.A.
author_facet Kern, T.S.
Tang, J.
Berkowitz, B.A.
author_sort Kern, T.S.
collection PubMed
description Diabetic retinopathy is a serious long-term complication of diabetes mellitus. There is considerable interest in using mouse models, which can be genetically modified, to understand how retinopathy develops and can be inhibited. Not all retinal lesions that develop in diabetic patients have been reproduced in diabetic mice; conversely, not all abnormalities found in diabetic mice have been studied or identified in diabetic patients. Thus, it is important to recognize which structural and functional abnormalities that develop in diabetic mice have been validated against the lesions that characteristically develop in diabetic patients. Those lesions that have been observed to develop in the mouse models to date are predominantly characteristic of the early stages of retinopathy. Identification of new therapeutic ways to inhibit these early lesions is expected to help inhibit progression to more advanced and clinically important stages of retinopathy.
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spelling pubmed-29943602010-12-06 Validation of structural and functional lesions of diabetic retinopathy in mice Kern, T.S. Tang, J. Berkowitz, B.A. Mol Vis Technical Brief Diabetic retinopathy is a serious long-term complication of diabetes mellitus. There is considerable interest in using mouse models, which can be genetically modified, to understand how retinopathy develops and can be inhibited. Not all retinal lesions that develop in diabetic patients have been reproduced in diabetic mice; conversely, not all abnormalities found in diabetic mice have been studied or identified in diabetic patients. Thus, it is important to recognize which structural and functional abnormalities that develop in diabetic mice have been validated against the lesions that characteristically develop in diabetic patients. Those lesions that have been observed to develop in the mouse models to date are predominantly characteristic of the early stages of retinopathy. Identification of new therapeutic ways to inhibit these early lesions is expected to help inhibit progression to more advanced and clinically important stages of retinopathy. Molecular Vision 2010-10-19 /pmc/articles/PMC2994360/ /pubmed/21139688 Text en Copyright © 2010 Molecular Vision. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Technical Brief
Kern, T.S.
Tang, J.
Berkowitz, B.A.
Validation of structural and functional lesions of diabetic retinopathy in mice
title Validation of structural and functional lesions of diabetic retinopathy in mice
title_full Validation of structural and functional lesions of diabetic retinopathy in mice
title_fullStr Validation of structural and functional lesions of diabetic retinopathy in mice
title_full_unstemmed Validation of structural and functional lesions of diabetic retinopathy in mice
title_short Validation of structural and functional lesions of diabetic retinopathy in mice
title_sort validation of structural and functional lesions of diabetic retinopathy in mice
topic Technical Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994360/
https://www.ncbi.nlm.nih.gov/pubmed/21139688
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