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Risk factors of HIV vertical transmission in a cohort of women under a PMTCT program at three peri-urban clinics in a resource-poor setting

OBJECTIVE: To identify the risk factors of HIV vertical transmission in pregnant women. STUDY DESIGN: Observational cohort study. Between 2002 and 2003, 479 HIV-infected pregnant women in a PMTCT (prevention of the mother-to-child transmission) program were followed up with their infants at delivery...

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Autores principales: Gumbo, F Z, Duri, K, Kandawasvika, G Q, Kurewa, N E, Mapingure, M P, Munjoma, M W, Rusakaniko, S, Chirenje, M Z, Stray-Pedersen, B
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994594/
https://www.ncbi.nlm.nih.gov/pubmed/20336078
http://dx.doi.org/10.1038/jp.2010.31
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author Gumbo, F Z
Duri, K
Kandawasvika, G Q
Kurewa, N E
Mapingure, M P
Munjoma, M W
Rusakaniko, S
Chirenje, M Z
Stray-Pedersen, B
author_facet Gumbo, F Z
Duri, K
Kandawasvika, G Q
Kurewa, N E
Mapingure, M P
Munjoma, M W
Rusakaniko, S
Chirenje, M Z
Stray-Pedersen, B
author_sort Gumbo, F Z
collection PubMed
description OBJECTIVE: To identify the risk factors of HIV vertical transmission in pregnant women. STUDY DESIGN: Observational cohort study. Between 2002 and 2003, 479 HIV-infected pregnant women in a PMTCT (prevention of the mother-to-child transmission) program were followed up with their infants at delivery, until 15 months with infant HIV testing. RESULTS: Of these 281 infants had a definitive HIV result by 15 months of age, and 31.7% of the infants become HIV infected. In univariate analysis the risk factor identified were presence of vaginal discharge, genital itchiness, genital ulcers, dysuria, abnormal breast and vaginal infections (Trichomonas, Bacteria vaginosis and Candida) in the mother at enrolment. In multivariate analysis vaginal infections risk ratio (RR) 1.72(1.03–2.88) and abnormal breast RR 4.36(2.89–6.58) were predictors of HIV vertical transmission. CONCLUSION: There is need to screen for vaginal infections (Trichomonas, Bacteria vaginosis and Candida) and examine pregnant women for mastitis to identify women at risk of HIV vertical transmission for prevention.
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spelling pubmed-29945942010-12-02 Risk factors of HIV vertical transmission in a cohort of women under a PMTCT program at three peri-urban clinics in a resource-poor setting Gumbo, F Z Duri, K Kandawasvika, G Q Kurewa, N E Mapingure, M P Munjoma, M W Rusakaniko, S Chirenje, M Z Stray-Pedersen, B J Perinatol Original Article OBJECTIVE: To identify the risk factors of HIV vertical transmission in pregnant women. STUDY DESIGN: Observational cohort study. Between 2002 and 2003, 479 HIV-infected pregnant women in a PMTCT (prevention of the mother-to-child transmission) program were followed up with their infants at delivery, until 15 months with infant HIV testing. RESULTS: Of these 281 infants had a definitive HIV result by 15 months of age, and 31.7% of the infants become HIV infected. In univariate analysis the risk factor identified were presence of vaginal discharge, genital itchiness, genital ulcers, dysuria, abnormal breast and vaginal infections (Trichomonas, Bacteria vaginosis and Candida) in the mother at enrolment. In multivariate analysis vaginal infections risk ratio (RR) 1.72(1.03–2.88) and abnormal breast RR 4.36(2.89–6.58) were predictors of HIV vertical transmission. CONCLUSION: There is need to screen for vaginal infections (Trichomonas, Bacteria vaginosis and Candida) and examine pregnant women for mastitis to identify women at risk of HIV vertical transmission for prevention. Nature Publishing Group 2010-11 2010-03-25 /pmc/articles/PMC2994594/ /pubmed/20336078 http://dx.doi.org/10.1038/jp.2010.31 Text en Copyright © 2010 Nature America, Inc. http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Original Article
Gumbo, F Z
Duri, K
Kandawasvika, G Q
Kurewa, N E
Mapingure, M P
Munjoma, M W
Rusakaniko, S
Chirenje, M Z
Stray-Pedersen, B
Risk factors of HIV vertical transmission in a cohort of women under a PMTCT program at three peri-urban clinics in a resource-poor setting
title Risk factors of HIV vertical transmission in a cohort of women under a PMTCT program at three peri-urban clinics in a resource-poor setting
title_full Risk factors of HIV vertical transmission in a cohort of women under a PMTCT program at three peri-urban clinics in a resource-poor setting
title_fullStr Risk factors of HIV vertical transmission in a cohort of women under a PMTCT program at three peri-urban clinics in a resource-poor setting
title_full_unstemmed Risk factors of HIV vertical transmission in a cohort of women under a PMTCT program at three peri-urban clinics in a resource-poor setting
title_short Risk factors of HIV vertical transmission in a cohort of women under a PMTCT program at three peri-urban clinics in a resource-poor setting
title_sort risk factors of hiv vertical transmission in a cohort of women under a pmtct program at three peri-urban clinics in a resource-poor setting
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994594/
https://www.ncbi.nlm.nih.gov/pubmed/20336078
http://dx.doi.org/10.1038/jp.2010.31
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