Evidence that Transcript Cleavage Is Essential for RNA Polymerase II Transcription and Cell Viability

During transcript elongation in vitro, backtracking of RNA polymerase II (RNAPII) is a frequent occurrence that can lead to transcriptional arrest. The polymerase active site can cleave the transcript during such backtracking, allowing transcription to resume. Transcript cleavage is either stimulate...

Descripción completa

Detalles Bibliográficos
Autores principales: Sigurdsson, Stefan, Dirac-Svejstrup, A. Barbara, Svejstrup, Jesper Q.
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994637/
https://www.ncbi.nlm.nih.gov/pubmed/20417599
http://dx.doi.org/10.1016/j.molcel.2010.02.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994637/
https://www.ncbi.nlm.nih.gov/pubmed/20417599
http://dx.doi.org/10.1016/j.molcel.2010.02.026

Ejemplares similares