Evidence that Transcript Cleavage Is Essential for RNA Polymerase II Transcription and Cell Viability

During transcript elongation in vitro, backtracking of RNA polymerase II (RNAPII) is a frequent occurrence that can lead to transcriptional arrest. The polymerase active site can cleave the transcript during such backtracking, allowing transcription to resume. Transcript cleavage is either stimulate...

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Detalles Bibliográficos
Autores principales: Sigurdsson, Stefan, Dirac-Svejstrup, A. Barbara, Svejstrup, Jesper Q.
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994637/
https://www.ncbi.nlm.nih.gov/pubmed/20417599
http://dx.doi.org/10.1016/j.molcel.2010.02.026

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