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Seroepidemiology of Dengue Virus in Mayotte, Indian Ocean, 2006
BACKGROUND: Although Dengue virus (DENV) circulation had been documented in neighbouring South-western Indian Ocean Islands, its presence in Mayotte is poorly characterised. To address this issue, we aimed to assess the seroprevalence of dengue IgG antibodies (DENV-IgG Ab) among the population and t...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994745/ https://www.ncbi.nlm.nih.gov/pubmed/21152441 http://dx.doi.org/10.1371/journal.pone.0014141 |
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author | Sissoko, Daouda Ezzedine, Khaled Giry, Claude Moendandzé, Amrat Lernout, Tinne D'Ortenzio, Eric Pettinelli, François Malvy, Denis |
author_facet | Sissoko, Daouda Ezzedine, Khaled Giry, Claude Moendandzé, Amrat Lernout, Tinne D'Ortenzio, Eric Pettinelli, François Malvy, Denis |
author_sort | Sissoko, Daouda |
collection | PubMed |
description | BACKGROUND: Although Dengue virus (DENV) circulation had been documented in neighbouring South-western Indian Ocean Islands, its presence in Mayotte is poorly characterised. To address this issue, we aimed to assess the seroprevalence of dengue IgG antibodies (DENV-IgG Ab) among the population and to investigate potential associations with individual and household characteristics. METHODS/PRINCIPAL FINDINGS: In November–December 2006 we conducted a cross-sectional serologic survey in Mayotte among 1,154 inhabitants aged ≥2 years by using a multistage cluster random sampling method. The overall prevalence of DENV-specific IgG antibodies (ELISA) was 22.73% (95% CI, 18.16–27.31). The age-specific seroprevalence increased with age (χ(2) for trend = 11.86, P<0.0006), and was linked with previous known outbreaks in this region. In multivariate analysis, older age, being born in the Comoros and living in a household with a low socioeconomic index were positively associated with DENV IgG antibody positivity. CONCLUSIONS: These findings document substantial prior exposure of the population of Mayotte to DENV and highlight the risk of severe illness due to the possibility of sequential DENV infections. Further investigations characterizing current DENV circulation patterns and associated serotypes are needed. |
format | Text |
id | pubmed-2994745 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-29947452010-12-08 Seroepidemiology of Dengue Virus in Mayotte, Indian Ocean, 2006 Sissoko, Daouda Ezzedine, Khaled Giry, Claude Moendandzé, Amrat Lernout, Tinne D'Ortenzio, Eric Pettinelli, François Malvy, Denis PLoS One Research Article BACKGROUND: Although Dengue virus (DENV) circulation had been documented in neighbouring South-western Indian Ocean Islands, its presence in Mayotte is poorly characterised. To address this issue, we aimed to assess the seroprevalence of dengue IgG antibodies (DENV-IgG Ab) among the population and to investigate potential associations with individual and household characteristics. METHODS/PRINCIPAL FINDINGS: In November–December 2006 we conducted a cross-sectional serologic survey in Mayotte among 1,154 inhabitants aged ≥2 years by using a multistage cluster random sampling method. The overall prevalence of DENV-specific IgG antibodies (ELISA) was 22.73% (95% CI, 18.16–27.31). The age-specific seroprevalence increased with age (χ(2) for trend = 11.86, P<0.0006), and was linked with previous known outbreaks in this region. In multivariate analysis, older age, being born in the Comoros and living in a household with a low socioeconomic index were positively associated with DENV IgG antibody positivity. CONCLUSIONS: These findings document substantial prior exposure of the population of Mayotte to DENV and highlight the risk of severe illness due to the possibility of sequential DENV infections. Further investigations characterizing current DENV circulation patterns and associated serotypes are needed. Public Library of Science 2010-11-30 /pmc/articles/PMC2994745/ /pubmed/21152441 http://dx.doi.org/10.1371/journal.pone.0014141 Text en Sissoko et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Sissoko, Daouda Ezzedine, Khaled Giry, Claude Moendandzé, Amrat Lernout, Tinne D'Ortenzio, Eric Pettinelli, François Malvy, Denis Seroepidemiology of Dengue Virus in Mayotte, Indian Ocean, 2006 |
title | Seroepidemiology of Dengue Virus in Mayotte, Indian Ocean, 2006 |
title_full | Seroepidemiology of Dengue Virus in Mayotte, Indian Ocean, 2006 |
title_fullStr | Seroepidemiology of Dengue Virus in Mayotte, Indian Ocean, 2006 |
title_full_unstemmed | Seroepidemiology of Dengue Virus in Mayotte, Indian Ocean, 2006 |
title_short | Seroepidemiology of Dengue Virus in Mayotte, Indian Ocean, 2006 |
title_sort | seroepidemiology of dengue virus in mayotte, indian ocean, 2006 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994745/ https://www.ncbi.nlm.nih.gov/pubmed/21152441 http://dx.doi.org/10.1371/journal.pone.0014141 |
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