Concomitant heterochromatinisation and down-regulation of gene expression unveils epigenetic silencing of RELB in an aggressive subset of chronic lymphocytic leukemia in males

BACKGROUND: The sensitivity of chronic lymphocytic leukemia (CLL) cells to current treatments, both in vitro and in vivo, relies on their ability to activate apoptotic death. CLL cells resistant to DNA damage-induced apoptosis display deregulation of a specific set of genes. METHODS: Microarray hybr...

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Detalles Bibliográficos
Autores principales: Marteau, Jean-Brice, Rigaud, Odile, Brugat, Thibaut, Gault, Nathalie, Vallat, Laurent, Kruhoffer, Mogens, Orntoft, Torben F, Nguyen-Khac, Florence, Chevillard, Sylvie, Merle-Beral, Hélène, Delic, Jozo
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994775/
https://www.ncbi.nlm.nih.gov/pubmed/21062507
http://dx.doi.org/10.1186/1755-8794-3-53

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