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Differences in the Pathways of Proteins Unfolding Induced by Urea and Guanidine Hydrochloride: Molten Globule State and Aggregates

It was shown that at low concentrations guanidine hydrochloride (GdnHCl) can cause aggregation of proteins in partially folded state and that fluorescent dye 1-anilinonaphthalene-8-sulfonic acid (ANS) binds with these aggregates rather than with hydrophobic clusters on the surface of protein in molt...

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Detalles Bibliográficos
Autores principales: Povarova, Olga I., Kuznetsova, Irina M., Turoverov, Konstantin K.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994796/
https://www.ncbi.nlm.nih.gov/pubmed/21152408
http://dx.doi.org/10.1371/journal.pone.0015035

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