The Immune Inhibitory Receptor LAIR-1 Is Highly Expressed by Plasmacytoid Dendritic Cells and Acts Complementary with NKp44 to Control IFNα Production

Plasmacytoid dendritic cells (pDCs) are a subset of dendritic cells endowed with the capacity of producing large amounts of IFNα. Here we show that the Leukocyte-Associated Ig-like Receptor-1 (LAIR-1) is abundantly expressed on pDCs (the highest expression among all leukocytes) and its cross-linking...

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Detalles Bibliográficos
Autores principales: Bonaccorsi, Irene, Cantoni, Claudia, Carrega, Paolo, Oliveri, Daniela, Lui, Gabrielle, Conte, Romana, Navarra, Michele, Cavaliere, Riccardo, Traggiai, Elisabetta, Gattorno, Marco, Martini, Alberto, Mingari, Maria Cristina, Moretta, Alessandro, Ferlazzo, Guido
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994815/
https://www.ncbi.nlm.nih.gov/pubmed/21151495
http://dx.doi.org/10.1371/journal.pone.0015080

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